(Q37363129)

19 August 2017

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title

Clinical implications of molecular genetic aberrations in acute myeloid leukemia (English)

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19 August 2017

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Sebastian Scholl

1

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19 August 2017

Hans-Joerg Fricke

series ordinal

2

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19 August 2017

Herbert G Sayer

series ordinal

3

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19 August 2017

Klaus Höffken

series ordinal

4

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19 August 2017

6 January 2009

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Journal of Cancer Research and Clinical Oncology

19 August 2017

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19 August 2017

135

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19 August 2017

4

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19 August 2017

491-505

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https://scigraph.springernature.com/pub.10.1007/s00432-008-0524-x

19 August 2017

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12 December 2020

Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia

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12 December 2020

Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration

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Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study

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High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.

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12 December 2020

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

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12 December 2020

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

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12 December 2020

Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study

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Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study

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12 December 2020

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

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12 December 2020

Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse

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12 December 2020

Implications of NRAS mutations in AML: a study of 2502 patients

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12 December 2020

BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study

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12 December 2020

Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML

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12 December 2020

Tipifarnib in acute myeloid leukemia

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12 December 2020

Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study

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12 December 2020

Risk assessment by monitoring expression levels of partial tandem duplications in the MLL gene in acute myeloid leukemia during therapy.

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12 December 2020

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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12 December 2020

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

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12 December 2020

Real-time quantitation of minimal residual disease in inv(16)-positive acute myeloid leukemia may indicate risk for clinical relapse and may identify patients in a curable state

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12 December 2020

Risk assessment in patients with acute myeloid leukemia and a normal karyotype

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12 December 2020

Detection of minimal residual disease in patients with AML1/ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay

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12 December 2020

High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics

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12 December 2020

Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML).

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12 December 2020

FLT3 length mutations as marker for follow-up studies in acute myeloid leukaemia

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12 December 2020

Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR.

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12 December 2020

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

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12 December 2020

Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML.

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12 December 2020

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

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12 December 2020

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.

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12 December 2020

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

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12 December 2020

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

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12 December 2020

Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.

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12 December 2020

BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia

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12 December 2020

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

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12 December 2020

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

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12 December 2020

Immunotherapeutic targeting of Wilms' tumor protein.

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12 December 2020

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

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12 December 2020

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

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12 December 2020

Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients.

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12 December 2020

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

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12 December 2020

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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12 December 2020

Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis

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12 December 2020

Proteomics of acute myeloid leukaemia: Cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications

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12 December 2020

Proteomic analysis of human acute leukemia cells: insight into their classification

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12 December 2020

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

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12 December 2020

Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations

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12 December 2020

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias

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12 December 2020

Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR

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12 December 2020

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

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12 December 2020

A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells

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12 December 2020

Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol

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12 December 2020

Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples

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12 December 2020

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

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12 December 2020

Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study

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12 December 2020

MN1, a novel player in human AML

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12 December 2020

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

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12 December 2020

Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations

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12 December 2020

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients

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12 December 2020

Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.

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12 December 2020

Functional proteomic profiling of AML predicts response and survival

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12 December 2020

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

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12 December 2020

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

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12 December 2020

High Expression Levels of theETS-Related Gene,ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

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12 December 2020

Farnesyltransferase inhibitor therapy in acute myelogenous leukemia.

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12 December 2020

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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12 December 2020

Rapid screening and sensitive detection of NPM1 (nucleophosmin) exon 12 mutations in acute myeloid leukaemia

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12 December 2020

MicroRNA expression in cytogenetically normal acute myeloid leukemia

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12 December 2020

Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibit

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12 December 2020

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

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12 December 2020

Prognostic value of minimal residual disease quantification by real-time reverse transcriptase polymerase chain reaction in patients with core binding factor leukemias

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12 December 2020

FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

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12 December 2020

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

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12 December 2020

Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group

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12 December 2020

PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

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12 December 2020

Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party

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12 December 2020

Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis

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12 December 2020

Prognostically useful gene-expression profiles in acute myeloid leukemia.

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12 December 2020

Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.

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12 December 2020

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

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12 December 2020

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

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12 December 2020

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

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12 December 2020

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

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12 December 2020

Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia

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12 December 2020

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

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12 December 2020

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

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12 December 2020

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

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12 December 2020

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

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12 December 2020

Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors

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12 December 2020

BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications.

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12 December 2020

An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML

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12 December 2020

High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CAL

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12 December 2020

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

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12 December 2020

The MLL recombinome of acute leukemias

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12 December 2020

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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12 December 2020

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

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12 December 2020

10.1007/S00432-008-0524-X

Identifiers

DOI

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19 August 2017

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