(Q37371624)

20 August 2017

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title

Epigenetic control of T-helper-cell differentiation (English)

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20 August 2017

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Christopher B Wilson

1

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20 August 2017

Emily Rowell

series ordinal

2

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20 August 2017

Masayuki Sekimata

series ordinal

3

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20 August 2017

1 February 2009

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Nature Reviews Immunology

20 August 2017

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20 August 2017

9

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20 August 2017

91-105

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20 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nri2487

20 August 2017

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cites work

Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

1 reference

Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human

21 January 2018

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IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection

21 January 2018

1 reference

Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii

21 January 2018

1 reference

Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.

21 January 2018

1 reference

Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.

21 January 2018

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Functional plasticity in memory T helper cell responses.

21 January 2018

1 reference

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

21 January 2018

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Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets

21 January 2018

1 reference

The biological functions of T helper 17 cell effector cytokines in inflammation

31 March 2020

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The lineage decisions of helper T cells

31 March 2020

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Regulation of Th2 differentiation and Il4 locus accessibility.

31 March 2020

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T helper cell differentiation: regulation by cis elements and epigenetics

31 March 2020

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Language: Disputed definitions

31 March 2020

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RNAi and chromatin in T cell development and function

31 March 2020

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Post-transcriptional control of cytokine production

31 March 2020

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MicroRNAs: new regulators of immune cell development and function

31 March 2020

1 reference

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

31 March 2020

1 reference

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

31 March 2020

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Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

31 March 2020

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Regulation of interferon-gamma during innate and adaptive immune responses

31 March 2020

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T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.

31 March 2020

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T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

31 March 2020

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T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription

31 March 2020

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

31 March 2020

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In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation

31 March 2020

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Transcriptional regulation of Th17 cell differentiation

31 March 2020

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Th17 cell differentiation: the long and winding road

31 March 2020

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

31 March 2020

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TH17 cells in development: an updated view of their molecular identity and genetic programming

31 March 2020

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T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

31 March 2020

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

31 March 2020

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

31 March 2020

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Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets.

31 March 2020

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

31 March 2020

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Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

31 March 2020

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

31 March 2020

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

31 March 2020

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A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

31 March 2020

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The complex language of chromatin regulation during transcription

31 March 2020

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Chromatin modifications and their function

31 March 2020

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Long-range regulation of cytokine gene expression.

31 March 2020

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Multivalent engagement of chromatin modifications by linked binding modules

31 March 2020

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DNA methylation and the expanding epigenetics of T cell lineage commitment

31 March 2020

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Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development

31 March 2020

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Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation

31 March 2020

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Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.

31 March 2020

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Genome-scale DNA methylation maps of pluripotent and differentiated cells

31 March 2020

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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

31 March 2020

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Facultative heterochromatin: is there a distinctive molecular signature?

31 March 2020

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Combinatorial patterns of histone acetylations and methylations in the human genome

31 March 2020

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Chromatin signatures of pluripotent cell lines

31 March 2020

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High-resolution profiling of histone methylations in the human genome

31 March 2020

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Helper T cell differentiation is controlled by the cell cycle

31 March 2020

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Histone deacetylation inhibits IL4 gene expression in T cells.

31 March 2020

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Gene silencing quantitatively controls the function of a developmental trans-activator

31 March 2020

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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

31 March 2020

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Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells

31 March 2020

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DNA methylation is a nonredundant repressor of the Th2 effector program

31 March 2020

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T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent

31 March 2020

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Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.

31 March 2020

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Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene

31 March 2020

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Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

31 March 2020

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Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

31 March 2020

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

31 March 2020

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The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

31 March 2020

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Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

31 March 2020

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Cell cycle controlling the silencing and functioning of mammalian activators.

31 March 2020

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Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region

31 March 2020

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Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.

31 March 2020

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EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells

31 March 2020

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Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development

31 March 2020

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Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

31 March 2020

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A critical control element for interleukin-4 memory expression in T helper lymphocytes

31 March 2020

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T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

31 March 2020

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Stat5 activation plays a critical role in Th2 differentiation

31 March 2020

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GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

31 March 2020

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

31 March 2020

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Demethylation of a specific hypersensitive site in the Th2 locus control region

31 March 2020

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BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells

31 March 2020

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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

31 March 2020

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Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma

31 March 2020

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A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.

31 March 2020

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Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells

31 March 2020

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High-resolution mapping and characterization of open chromatin across the genome

31 March 2020

1 reference

Long-range transcriptional regulation of cytokine gene expression.

31 March 2020

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A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

31 March 2020

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Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells

31 March 2020

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Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells.

31 March 2020

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Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation

31 March 2020

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Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination

31 March 2020

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Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals.

31 March 2020

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

31 March 2020

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

31 March 2020

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Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells

31 March 2020

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T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects

31 March 2020

1 reference

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

31 March 2020

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T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site

31 March 2020

1 reference

Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes

31 March 2020

1 reference

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

31 March 2020

1 reference

A novel transcription factor, T-bet, directs Th1 lineage commitment

31 March 2020

1 reference

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

31 March 2020

1 reference

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

31 March 2020

1 reference

Gene regulation in the third dimension

31 March 2020

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Beyond the sequence: cellular organization of genome function

31 March 2020

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The role of CTCF in regulating nuclear organization

31 March 2020

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Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

31 March 2020

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SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.

31 March 2020

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Genetics and epigenetics of the multifunctional protein CTCF.

31 March 2020

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Cohesins functionally associate with CTCF on mammalian chromosome arms

31 March 2020

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Interchromosomal associations between alternatively expressed loci

31 March 2020

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Unconventional association of the polycomb group proteins with cytokine genes in differentiated T helper cells

31 March 2020

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Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet

31 March 2020

1 reference

Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation

31 March 2020

1 reference

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

31 March 2020

1 reference

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

31 March 2020

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GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

31 March 2020

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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

31 March 2020

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Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression

31 March 2020

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

31 March 2020

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Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

31 March 2020

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

31 March 2020

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Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

31 March 2020

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Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.

31 March 2020

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

31 March 2020

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T(H)-17 differentiation: of mice and men

31 March 2020

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Development, cytokine profile and function of human interleukin 17-producing helper T cells

31 March 2020

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Phenotypic and functional features of human Th17 cells

31 March 2020

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Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

31 March 2020

1 reference

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

31 March 2020

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

31 March 2020

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TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

31 March 2020

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T(H)1 cells control themselves by producing interleukin-10.

31 March 2020

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Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

31 March 2020

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Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors

31 March 2020

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Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.

31 March 2020

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Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate.

31 March 2020

1 reference

New nomenclature for chromatin-modifying enzymes

31 March 2020

1 reference

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

31 March 2020

1 reference

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

31 March 2020

1 reference

Late developmental plasticity in the T helper 17 lineage

31 March 2020

1 reference

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

31 March 2020

1 reference

The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19151746

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19151746

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19151746

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2487

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Dimensions Publication ID

20 August 2017

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1 reference