(Q3737406)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05177

cytochrome P450, E-class, group I, CYP1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05177

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

3 references

8 April 2019

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

caffeine oxidase activity

1 reference

8 April 2019

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

IPI

oxidoreductase activity

3 references

8 April 2019

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

electron transfer activity

1 reference

8 April 2019

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

monooxygenase activity

5 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

24 April 2018

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

24 April 2018

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

monooxygenase activity

6 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

intracellular membrane-bounded organelle

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

24 April 2018

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

endoplasmic reticulum

1 reference

8 April 2019

intracellular membrane-bounded organelle

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

response to immobilization stress

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

toxin metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

steroid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

alkaloid metabolic process

1 reference

8 April 2019

Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

epoxygenase P450 pathway

1 reference

8 April 2019

cellular response to cadmium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

post-embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

monocarboxylic acid metabolic process

1 reference

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

oxidative demethylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

steroid catabolic process

1 reference

8 April 2019

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

omega-hydroxylase P450 pathway

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

dibenzo-p-dioxin metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

heterocycle metabolic process

1 reference

8 April 2019

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

cellular aromatic compound metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

hydrogen peroxide biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

monoterpenoid metabolic process

1 reference

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

xenobiotic metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

porphyrin-containing compound metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

toxin biosynthetic process

1 reference

8 April 2019

Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

cellular response to copper ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

electron transport chain

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

long-chain fatty acid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177

physically interacts with

liver kidney microsomal type 3 antibody

subject has role

antigen

0 references

Gene Atlas image

PBB GE CYP1A2 207609 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

cytochrome P450, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05177

Identifiers

MeSH descriptor ID

D019388

subject named as

Cytochrome P-450 CYP1A2

0 references

MeSH tree code

D08.244.453.005.443

0 references

D08.244.453.100.750

0 references

D08.811.682.690.708.170.010.443

0 references

D08.811.682.690.708.170.020.750

0 references

D12.776.422.220.453.010.443

0 references

D12.776.422.220.453.100.750

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata