(Q37374120)

English

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

scientific article published on 23 May 2009

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site (English)

1 reference

Europe PubMed Central

20 August 2017

author name string

Dana M van Bemmel

1

1 reference

Europe PubMed Central

20 August 2017

Adam S Brank

2

1 reference

Europe PubMed Central

20 August 2017

Ramon Eritja

3

1 reference

Europe PubMed Central

20 August 2017

Victor E Marquez

4

1 reference

Europe PubMed Central

20 August 2017

Judith K Christman

5

1 reference

Europe PubMed Central

20 August 2017

language of work or name

0 references

publication date

23 May 2009

1 reference

Europe PubMed Central

20 August 2017

Biochemical Pharmacology

1 reference

Europe PubMed Central

20 August 2017

78

1 reference

Europe PubMed Central

20 August 2017

6

1 reference

Europe PubMed Central

20 August 2017

633-641

1 reference

Europe PubMed Central

20 August 2017

DNA cytosine C5 methyltransferase Dnmt1: catalysis-dependent release of allosteric inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756644

6 September 2017

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756644

6 September 2017

Inhibition of HhaI DNA (Cytosine-C5) methyltransferase by oligodeoxyribonucleotides containing 5-aza-2'-deoxycytidine: examination of the intertwined roles of co-factor, target, transition state structure and enzyme conformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756644

6 September 2017

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756644

6 September 2017

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

1 reference

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Optimization of baculovirus-mediated expression and purification of hexahistidine-tagged murine DNA (cytosine-C5)-methyltransferase-1 in Spodoptera frugiperda 9 cells

1 reference

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Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

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A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

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Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients

1 reference

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Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine

1 reference

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Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base

1 reference

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DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase

1 reference

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Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

1 reference

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Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

1 reference

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6 September 2017

Effects of co-factor and deoxycytidine substituted oligonucleotides upon sequence-specific interactions between MspI DNA methyltransferase and DNA.

1 reference

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Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex

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6 September 2017

5-Aza-2'-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trends

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6 September 2017

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756644

6 September 2017

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756644

6 September 2017

The synthesis of 2-pyrimidinone nucleosides and their incorporation into oligodeoxynucleotides

1 reference

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A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions

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Mode of action and effects of 5-azacytidine and of its derivatives in eukaryotic cells

1 reference

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells

1 reference

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DNA Methylation in Friend Erythroleukemia Cells: The Effects of Chemically Induced Differentiation and of Treatment with Inhibitors of DNA Methylation

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5-Azacytidine, DNA Methylation, and Differentiation

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Inhibition of cytidine deaminase by 2-oxopyrimidine riboside and related compounds.

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Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites

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A phase II study of 5-aza-2'deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer.

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DNA methylation, genomic imprinting, and mammalian development

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Cellular differentiation, cytidine analogs and DNA methylation

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Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase

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Mutagenicity of the cytidine analog zebularine in Escherichia coli

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Identifiers

10.1016/J.BCP.2009.05.017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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