(Q38362249)

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Inhibition of HhaI DNA (Cytosine-C5) methyltransferase by oligodeoxyribonucleotides containing 5-aza-2'-deoxycytidine: examination of the intertwined roles of co-factor, target, transition state structure and enzyme conformation.

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13 December 2019

Inhibition of HhaI DNA (Cytosine-C5) methyltransferase by oligodeoxyribonucleotides containing 5-aza-2'-deoxycytidine: examination of the intertwined roles of co-factor, target, transition state structure and enzyme conformation (English)

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13 December 2019

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13 December 2019

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Adam S Brank

1

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13 December 2019

Ramon Guimil Garcia

3

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13 December 2019

Victor E Marquez

4

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13 December 2019

Judith K Christman

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1 October 2002

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13 December 2019

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Journal of Molecular Biology

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13 December 2019

323

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13 December 2019

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13 December 2019

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13 December 2019

DNA hypomethylation leads to elevated mutation rates

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Role for DNA methylation in genomic imprinting

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Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells

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Hypomethylation of DNA from benign and malignant human colon neoplasms

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High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer

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DNA methylation differences associated with tumor tissues identified by genome scanning analysis

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Hypermethylation of the cell cycle inhibitor p15INK4b 3'-untranslated region interferes with its transcriptional regulation in primary lymphomas.

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Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis

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Mitoxantrone and 5-azacytidine for refractory/relapsed ANLL or CML in blast crisis: a leukemia intergroup study.

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Fetal hemoglobin levels in adults

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A phase II study of 5-aza-2'deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer.

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Potential of 5-aza-2'-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer

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7 January 2021

Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients

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A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

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Phase II trial of paclitaxel and ifosfamide as a salvage treatment in metastatic breast cancer

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Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia.

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DNA Methylation in Friend Erythroleukemia Cells: The Effects of Chemically Induced Differentiation and of Treatment with Inhibitors of DNA Methylation

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7 January 2021

Stabilization of 5-azacytidine by nucleophilic addition of bisulfite ion

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7 January 2021

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

1 reference

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7 January 2021

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

1 reference

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7 January 2021

Universal catalytic domain structure of AdoMet-dependent methyltransferases.

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7 January 2021

The DNA (cytosine-5) methyltransferases

1 reference

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7 January 2021

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine

1 reference

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7 January 2021

HhaI methyltransferase flips its target base out of the DNA helix

1 reference

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7 January 2021

Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

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7 January 2021

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base

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7 January 2021

Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine

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7 January 2021

The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor

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Binding of the EcoRII methylase to azacytosine-containing DNA.

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Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

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Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine

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Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites

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DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells

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Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution.

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M.HhaI binds tightly to substrates containing mismatches at the target base

1 reference

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7 January 2021

A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase

1 reference

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Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.

1 reference

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Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex.

1 reference

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Structure-based sequence alignment of three AdoMet-dependent DNA methyltransferases

1 reference

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7 January 2021

Identifiers

10.1016/S0022-2836(02)00918-X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12368098%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

Europe PubMed Central

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13 December 2019

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