(Q37377515)

English

Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

scientific article published on September 2009

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scholarly article

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7 February 2020

Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling (English)

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7 February 2020

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7 February 2020

author name string

Tao Ma

1

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7 February 2020

YongBo Zhao

2

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7 February 2020

Young-Don Kwak

3

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7 February 2020

Zhangmin Yang

4

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7 February 2020

Robert Thompson

5

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7 February 2020

Huaxi Xu

7

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7 February 2020

Francesca-Fang Liao

8

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7 February 2020

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publication date

1 September 2009

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7 February 2020

Journal of Neuroscience

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7 February 2020

29

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7 February 2020

36

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7 February 2020

11226-11236

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7 February 2020

Rho kinase in the regulation of cell death and survival

1 reference

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6 September 2017

NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression.

1 reference

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6 September 2017

Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects.

1 reference

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6 September 2017

Can statins put the brakes on Alzheimer's disease?

1 reference

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6 September 2017

Statins in stroke: prevention, protection and recovery

1 reference

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6 September 2017

Isoprenoids and Alzheimer's disease: a complex relationship

1 reference

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6 September 2017

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death

1 reference

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6 September 2017

Pleiotropic effects of statins

1 reference

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6 September 2017

Regulation of PTEN by Rho small GTPases

1 reference

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6 September 2017

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

1 reference

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6 September 2017

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

1 reference

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6 September 2017

Calpain and its involvement in the pathophysiology of CNS injuries and diseases: therapeutic potential of calpain inhibitors for prevention of neurodegeneration

1 reference

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6 September 2017

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

1 reference

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6 September 2017

Statins and neuroprotection

1 reference

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6 September 2017

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

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6 September 2017

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

1 reference

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6 September 2017

A simplified system for generating recombinant adenoviruses

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Protein prenylation: molecular mechanisms and functional consequences

1 reference

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6 September 2017

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

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6 September 2017

Glutamate neurotoxicity and diseases of the nervous system

1 reference

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6 September 2017

Statins reduce amyloid-beta production through inhibition of protein isoprenylation

1 reference

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14 September 2017

Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.

1 reference

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14 September 2017

Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration

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14 September 2017

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

1 reference

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14 September 2017

Mechanisms of statin-mediated inhibition of small G-protein function

1 reference

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14 September 2017

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

1 reference

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14 September 2017

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding

1 reference

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14 September 2017

Signalling activity of beta-catenin targeted to different subcellular compartments

1 reference

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14 September 2017

Calcium: still center-stage in hypoxic-ischemic neuronal death

1 reference

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14 September 2017

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

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28 September 2017

Membrane association and targeting of prenylated Ras-like GTPases

1 reference

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28 September 2017

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

1 reference

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Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

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26 June 2018

N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.

1 reference

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2 September 2018

RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion

1 reference

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2 September 2018

Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones

1 reference

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2 September 2018

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity.

1 reference

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2 September 2018

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.

1 reference

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2 September 2018

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1 reference

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

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Identifiers

10.1523/JNEUROSCI.6150-08.2009

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7 February 2020

1 reference

Europe PubMed Central

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7 February 2020

1 reference

Europe PubMed Central

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7 February 2020

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