(Q37379780)

20 August 2017

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title

Heterologous expression systems for polyketide synthases (English)

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20 August 2017

Isao Fujii

1

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20 August 2017

9 December 2008

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20 August 2017

Natural Product Reports

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20 August 2017

26

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20 August 2017

155-169

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20 August 2017

2

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Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads

20 August 2017

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Native acridone synthases I and II from Ruta graveolens L. form homodimers

21 January 2018

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Site-directed mutagenesis of benzalacetone synthase. The role of the Phe215 in plant type III polyketide synthases

21 January 2018

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The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide

21 January 2018

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A plant type III polyketide synthase that produces pentaketide chromone

21 January 2018

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Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase

21 January 2018

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Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens

21 January 2018

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Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone.

21 January 2018

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A polyketide synthase of Plumbago indica that catalyzes the formation of hexaketide pyrones

21 January 2018

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In vitro synthesis of curcuminoids by type III polyketide synthase from Oryza sativa

21 January 2018

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A type III polyketide synthase from Wachendorfia thyrsiflora and its role in diarylheptanoid and phenylphenalenone biosynthesis

21 January 2018

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A new pathway for polyketide synthesis in microorganisms.

21 January 2018

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A new family of type III polyketide synthases in Mycobacterium tuberculosis

21 January 2018

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A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites

21 January 2018

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Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates

21 January 2018

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Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining

21 January 2018

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Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii

21 January 2018

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Biosynthesis of phloroglucinol

21 January 2018

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Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens.

21 January 2018

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Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzae

21 January 2018

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Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.

21 January 2018

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Engineered biosynthesis of novel polyketides

21 January 2018

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Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

21 January 2018

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Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus

21 January 2018

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Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

21 January 2018

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Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.

21 January 2018

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Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction

21 January 2018

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Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases

21 January 2018

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Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase

21 January 2018

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Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase.

21 January 2018

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An antibiotic factory caught in action

21 January 2018

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Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57.

21 January 2018

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Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

21 January 2018

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Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase.

21 January 2018

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Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes.

21 January 2018

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An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation

21 January 2018

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Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase.

21 January 2018

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Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

21 January 2018

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Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

21 January 2018

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Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase.

21 January 2018

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Deconstruction of iterative multidomain polyketide synthase function.

21 January 2018

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Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB.

21 January 2018

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Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi

21 January 2018

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A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae

21 January 2018

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Modular organization of genes required for complex polyketide biosynthesis

21 January 2018

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Engineered biosynthesis of a complete macrolactone in a heterologous host

21 January 2018

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Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae

21 January 2018

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Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

21 January 2018

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Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

21 January 2018

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Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae.

21 January 2018

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Construction of thiostrepton-inducible, high-copy-number expression vectors for use in Streptomyces spp.

21 January 2018

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Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase.

21 January 2018

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Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation

21 January 2018

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Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production

21 January 2018

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Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster.

21 January 2018

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

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Production of the potent antibacterial polyketide erythromycin C in Escherichia coli

21 January 2018

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Rational design and assembly of synthetic trimodular polyketide synthases.

21 January 2018

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Heterologous production of epothilone C and D in Escherichia coli.

21 January 2018

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21 January 2018

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Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

21 January 2018

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New pathway to polyketides in plants

21 January 2018

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Alternative modular polyketide synthase expression controls macrolactone structure

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B817092B

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20 August 2017

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PubMed ID

19177221