(Q37395697)

20 August 2017

Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis (English)

1 reference

20 August 2017

0 references

endoplasmic reticulum

0 references

1 reference

Kelly Ruggles

7

0 references

author name string

Donna M Conlon

1

1 reference

20 August 2017

Tiffany Thomas

2

1 reference

20 August 2017

Tatyana Fedotova

3

1 reference

20 August 2017

Antonio Hernandez-Ono

4

1 reference

20 August 2017

Gilbert Di Paolo

5

1 reference

20 August 2017

Robin B Chan

6

1 reference

20 August 2017

Sarah Gibeley

8

1 reference

20 August 2017

Jing Liu

9

1 reference

20 August 2017

Henry N Ginsberg

10

1 reference

20 August 2017

language of work or name

English

0 references

publication date

6 September 2016

1 reference

Journal of Clinical Investigation

20 August 2017

1 reference

20 August 2017

126

1 reference

20 August 2017

10

1 reference

20 August 2017

3852-3867

1 reference

describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5096813/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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A Role for Macro-ER-Phagy in ER Quality Control

6 September 2017

1 reference

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Regulation of endoplasmic reticulum turnover by selective autophagy

6 September 2017

1 reference

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Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

6 September 2017

1 reference

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Dynamics of autophagosome formation: a pulse and a sequence of waves

6 September 2017

1 reference

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6 September 2017

Lipid droplet biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver?

6 September 2017

1 reference

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From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.

6 September 2017

1 reference

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The lipid kinase PI4KIIIβ preserves lysosomal identity

6 September 2017

1 reference

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Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

6 September 2017

1 reference

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Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

6 September 2017

1 reference

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The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

6 September 2017

1 reference

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Lumenal lipid metabolism: implications for lipoprotein assembly

6 September 2017

1 reference

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Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

6 September 2017

1 reference

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Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

6 September 2017

1 reference

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Coordination of autophagy and the proteasome in resolving endoplasmic reticulum stress

6 September 2017

1 reference

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Regulation of mammalian autophagy in physiology and pathophysiology.

6 September 2017

1 reference

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Autophagy and Regulation of Lipid Metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to-lysosome fusion and degradation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Autophagy regulates lipid metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

How to interpret LC3 immunoblotting

6 September 2017

1 reference

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Proteolytic and lipolytic responses to starvation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

ER stress and the unfolded protein response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Synthesis and function of hepatic very-low-density lipoprotein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Recent progress in understanding apolipoprotein B.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Subcellular localization of B apoprotein of plasma lipoproteins in rat liver

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Lipophagy: connecting autophagy and lipid metabolism

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Lysosomal positioning coordinates cellular nutrient responses.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Future challenges for microsomal transport protein inhibitors.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Restoration of autophagy alleviates hepatic ER stress and impaired insulin signalling transduction in high fructose-fed male mice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

ER-phagy: selective autophagy of the endoplasmic reticulum.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Endoplasmic reticulum stress: a new pathway to induce autophagy.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096813

Is the cholesteryl ester transfer protein proatherogenic or antiatherogenic in humans?

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27599291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of autophagy promotes caspase-mediated apoptosis by tunicamycin in HepG2 cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27599291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI86028

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

27599291

1 reference