(Q37402748)

English

The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract

scientific article published on 16 July 2009

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scholarly article

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Europe PubMed Central

PMC publication ID

20 August 2017

The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

8

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Garold S Yost

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Jaime D'Agostino

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Xiaoliang Zhuo

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Mohammad Shadid

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Daniel G Morgan

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Xiuling Zhang

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

W Griffith Humphreys

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Yue-Zhong Shu

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Xinxin Ding

9

1 reference

Europe PubMed Central

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20 August 2017

language of work or name

1 reference

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inferred from title

publication date

16 July 2009

1 reference

Europe PubMed Central

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20 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

37

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

2018-2027

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

COLONIC ABSORPTION OF TRYPTOPHAN METABOLITES IN MAN

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Bioactivation of toxicants by cytochrome p450-mediated dehydrogenation mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Mechanisms of 3-methylindole pneumotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

Nonneoplastic changes in the olfactory epithelium--experimental studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

6 September 2017

3-methylindole-induced toxicity to human bronchial epithelial cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

14 September 2017

Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

28 September 2017

Mechanistic studies on the cytochrome P450-catalyzed dehydrogenation of 3-methylindole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

26 June 2018

Inhibition of 3-methylindole bioactivation by the cytochrome P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

26 June 2018

Tobacco-specific nitrosamines in European and USA cigarettes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

26 June 2018

Metabolic activation of the pneumotoxin, 3-methylindole, by vaccinia-expressed cytochrome P450s

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

26 June 2018

Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Metabolism and bioactivation of 3-methylindole by human liver microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Detection and characterization of DNA adducts of 3-methylindole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Thioether adducts of a new imine reactive intermediate of the pneumotoxin 3-methylindole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769036

2 September 2018

Quantitative determination of 1-alkylindoles in cigarette smoke

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathology and glutathione status in 3-methylindole-treated rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of 3-methylindole in human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based enzyme inactivators

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19608696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.109.027300

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

ResearchGate publication ID

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