(Q37404716)

20 August 2017

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title

Interleukin-23/Th17 pathways and inflammatory bowel disease (English)

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inflammatory bowel diseases

20 August 2017

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2

Judy Cho

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20 August 2017

Clara Abraham

1

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20 August 2017

1 July 2009

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Inflammatory Bowel Diseases

20 August 2017

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20 August 2017

15

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20 August 2017

1090-1100

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20 August 2017

7

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Interleukin-23 drives innate and T cell-mediated intestinal inflammation

20 August 2017

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IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

21 January 2018

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

21 January 2018

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

21 January 2018

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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

21 January 2018

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Development, cytokine profile and function of human interleukin 17-producing helper T cells

21 January 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

21 January 2018

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

21 January 2018

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

21 January 2018

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Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

21 January 2018

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IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity

21 January 2018

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 January 2018

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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

21 January 2018

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Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

21 January 2018

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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

21 January 2018

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

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TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells.

21 January 2018

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IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection

21 January 2018

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Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.

21 January 2018

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Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages

21 January 2018

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Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

21 January 2018

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IL-25 regulates Th17 function in autoimmune inflammation

21 January 2018

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Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

21 January 2018

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Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

21 January 2018

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IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

21 January 2018

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IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes

21 January 2018

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

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Distinct regulation of interleukin-17 in human T helper lymphocytes

21 January 2018

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STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

21 January 2018

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T(H)-17 cells in the circle of immunity and autoimmunity

21 January 2018

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

21 January 2018

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IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants

21 January 2018

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Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells

21 January 2018

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Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice

21 January 2018

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ATP drives lamina propria T(H)17 cell differentiation

21 January 2018

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Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

21 January 2018

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 January 2018

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

21 January 2018

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IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

21 January 2018

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Interleukin-17 family members and inflammation

21 January 2018

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

21 January 2018

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The biological functions of T helper 17 cell effector cytokines in inflammation

21 January 2018

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

21 January 2018

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IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human.

21 January 2018

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

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IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

21 January 2018

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

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Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

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TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

21 January 2018

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Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion

21 January 2018

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Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

21 January 2018

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IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

21 January 2018

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T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

21 January 2018

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A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

21 January 2018

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Regulation of gut inflammation and th17 cell response by interleukin-21.

21 January 2018

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Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

21 January 2018

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Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

21 January 2018

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Phenotypic and functional features of human Th17 cells

21 January 2018

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T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

21 January 2018

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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells

21 January 2018

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Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

21 January 2018

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Interleukin-17 is a negative regulator of established allergic asthma

21 January 2018

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T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

21 January 2018

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Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis

21 January 2018

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

21 January 2018

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In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells

21 January 2018

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Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

21 January 2018

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Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

21 January 2018

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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

21 January 2018

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Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha

21 January 2018

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CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

21 January 2018

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

21 January 2018

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Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

21 January 2018

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Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

21 January 2018

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Negative regulation of IL-17 production by OX40/OX40L interaction

21 January 2018

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Inducible costimulator is essential for collagen-induced arthritis

21 January 2018

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Role of TL1A and its receptor DR3 in two models of chronic murine ileitis

21 January 2018

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Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease

21 January 2018

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TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

21 January 2018

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Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease.

21 January 2018

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TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

21 January 2018

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Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation

21 January 2018

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Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

21 January 2018

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Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

21 January 2018

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Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response

21 January 2018

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Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

21 January 2018

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Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

21 January 2018

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Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine

21 January 2018

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Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.

21 January 2018

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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

21 January 2018

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Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

21 January 2018

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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

21 January 2018

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Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

21 January 2018

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Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

21 January 2018

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Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity.

21 January 2018

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IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts

21 January 2018

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Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells.

21 January 2018

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Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.

21 January 2018

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STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

21 January 2018

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Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

21 January 2018

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Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

21 January 2018

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IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

21 January 2018

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Increased expression of interleukin 17 in inflammatory bowel disease

21 January 2018

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Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

21 January 2018

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IL-23/IL-17 immunity as a hallmark of Crohn's disease

21 January 2018

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IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

21 January 2018

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Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.

21 January 2018

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Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.

21 January 2018

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

21 January 2018

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IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

21 January 2018

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IL23R haplotypes provide a large population attributable risk for Crohn's disease

21 January 2018

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IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

21 January 2018

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Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease

21 January 2018

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IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland

21 January 2018

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Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype

21 January 2018

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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

21 January 2018

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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

21 January 2018

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

21 January 2018

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Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

21 January 2018

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TNFSF15 is an ethnic-specific IBD gene

21 January 2018

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Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation

21 January 2018

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A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

21 January 2018

1 reference

Anti-interleukin-12 antibody for active Crohn's disease

21 January 2018

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A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease

21 January 2018

1 reference

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IBD.20894

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20 August 2017

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PubMed ID

19253307