(Q37421153)

20 August 2017

1 reference

title

Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress (English)

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20 August 2017

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8

Michael Torzewski

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20 August 2017

Andreas Daiber

1

1 reference

20 August 2017

Matthias Oelze

2

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20 August 2017

Philip Wenzel

3

1 reference

20 August 2017

Jennifer M Dias Wickramanayake

4

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20 August 2017

Swenja Schuhmacher

5

1 reference

20 August 2017

Thomas Jansen

6

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20 August 2017

Karl J Lackner

7

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20 August 2017

Thomas Münzel

9

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20 August 2017

publication date

1 January 2009

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20 August 2017

published in

Pharmacological Reports

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20 August 2017

volume

61

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20 August 2017

issue

1

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20 August 2017

page(s)

33-48

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Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin

20 August 2017

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Mechanisms of action of the organic nitrates in the treatment of myocardial ischemia

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Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

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Redox regulation of vascular prostanoid synthesis by the nitric oxide-superoxide system.

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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

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7 January 2021

Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium-dependent mechanism

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7 January 2021

Triggering mitochondrial radical release: a new function for NADPH oxidases

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7 January 2021

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

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7 January 2021

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

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7 January 2021

Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase

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7 January 2021

Identification of the enzymatic mechanism of nitroglycerin bioactivation

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7 January 2021

Vascular tolerance to nitroglycerin in ascorbate deficiency: results are in favour of an important role of oxidative stress in nitrate tolerance

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7 January 2021

Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates

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7 January 2021

Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure

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7 January 2021

Heterozygous deficiency of manganese superoxide dismutase in mice (Mn-SOD+/-): a novel approach to assess the role of oxidative stress for the development of nitrate tolerance

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7 January 2021

New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance

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7 January 2021

Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice

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7 January 2021

Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction

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7 January 2021

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

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7 January 2021

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion

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7 January 2021

The role of lipoic acid in prevention of nitroglycerin tolerance.

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7 January 2021

Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis

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7 January 2021

Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants

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7 January 2021

Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia

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7 January 2021

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

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7 January 2021

p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats

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7 January 2021

Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved?

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7 January 2021

Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity

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7 January 2021

Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease.

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7 January 2021

Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers

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7 January 2021

Nitroglycerin protects the endothelium from ischaemia and reperfusion: human mechanistic insight.

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7 January 2021

Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS.

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7 January 2021

Oxidative stress and cardiovascular injury: Part II: animal and human studies

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https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

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7 January 2021

Oxidative stress and vascular disease: 2005 Duff lecture

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https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

1 reference

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7 January 2021

Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance

1 reference

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7 January 2021

Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina

1 reference

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7 January 2021

Sulfhydryl reactivity of organic nitrates: biochemical basis for inhibition of glyceraldehyde-P dehydrogenase and monoamine oxidase.

1 reference

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7 January 2021

Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study

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7 January 2021

Evidence for a causal role of the renin-angiotensin system in nitrate tolerance

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7 January 2021

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

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7 January 2021

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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7 January 2021

Myeloperoxidase and its contributory role in inflammatory vascular disease.

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7 January 2021

Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore

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7 January 2021

Angiotensin II-receptor antagonist losartan does not prevent nitroglycerin tolerance in patients with coronary artery disease.

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7 January 2021

Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice

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7 January 2021

The angiotensin II-receptor antagonist losartan does not prevent hemodynamic or vascular tolerance to nitroglycerin

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Mitochondrial oxidative stress and nitrate tolerance--comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Explaining the phenomenon of nitrate tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Evidence for a role of oxygen-derived free radicals and protein kinase C in nitrate tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies. Multicenter Myocardial Ischemia Research Group

1 reference

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7 January 2021

Endothelial Protection by Pentaerithrityl Trinitrate: Bilirubin and Carbon Monoxide as Possible Mediators

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.

1 reference

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7 January 2021

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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7 January 2021

The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

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7 January 2021

Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models

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7 January 2021

Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion

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7 January 2021

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease

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7 January 2021

Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment

1 reference

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7 January 2021

Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis

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7 January 2021

Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

1 reference

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7 January 2021

Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism

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7 January 2021

Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress

1 reference

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7 January 2021

Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.

1 reference

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7 January 2021

Erythrocyte aldehyde dehydrogenase and disulfiram-like side effects of hypoglycemics and antianginals

1 reference

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7 January 2021

Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Endothelial nitric oxide and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction.

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7 January 2021

ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties

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7 January 2021

Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates

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7 January 2021

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

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https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications

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https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain

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https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970005-2

7 January 2021

10.1016/S1734-1140(09)70005-2

Identifiers

DOI

1 reference

20 August 2017

1 reference