(Q37421620)

English

Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases

scientific article published on August 2006

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scholarly article

1 reference

Europe PubMed Central

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28 December 2019

Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases (English)

1 reference

Europe PubMed Central

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28 December 2019

Gavin P. Robertson

8

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28 December 2019

author name string

Arati Sharma

1

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28 December 2019

Melissa A Tran

2

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28 December 2019

Shile Liang

3

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28 December 2019

Arun K Sharma

4

1 reference

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28 December 2019

Shantu Amin

5

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28 December 2019

Charles D Smith

6

1 reference

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28 December 2019

Cheng Dong

7

1 reference

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28 December 2019

language of work or name

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publication date

1 August 2006

1 reference

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28 December 2019

Cancer Research

1 reference

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28 December 2019

66

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28 December 2019

16

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28 December 2019

8200-8209

1 reference

Europe PubMed Central

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28 December 2019

Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment

1 reference

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23 August 2017

Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review.

1 reference

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23 August 2017

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Oncogenic Ras in tumour progression and metastasis

1 reference

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23 August 2017

Melanoma genetics and the development of rational therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

The gene expression signatures of melanoma progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Deregulated Akt3 activity promotes development of malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Stimulation of angiogenesis by Ras proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Raf pathway inhibitors in oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Mutations of the BRAF gene in benign and malignant melanocytic lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

BRAF as a potential therapeutic target in melanoma and other malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Metastasis suppressor pathways--an evolving paradigm.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Neutrophils influence melanoma adhesion and migration under flow conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Apoptosis and melanoma chemoresistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Raf proteins and cancer: B-Raf is identified as a mutational target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

The Ras-Raf-MEK-ERK pathway in the treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

High frequency of BRAF mutations in nevi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Design and discovery of small molecules targeting raf-1 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Mutations of the BRAF gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

In vitro characterization and micromechanics of tumor cell chemotactic protrusion, locomotion, and extravasation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Discovery of a novel Raf kinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

The chemoresistance of human malignant melanoma: an update.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Signaling pathways in Ras-mediated tumorigenicity and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

14 September 2017

Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

14 September 2017

V599EB-RAF is an oncogene in melanocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

14 September 2017

Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

14 September 2017

A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

14 September 2017

Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

28 September 2017

Shear stress and shear rate differentially affect the multi-step process of leukocyte-facilitated melanoma adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

26 June 2018

Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas

1 reference

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2 September 2018

BRAF mutations in metastatic melanoma: a possible association with clinical outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

2 September 2018

BRAF as a melanoma susceptibility candidate gene?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

2 September 2018

Absence of exon 15 BRAF germline mutations in familial melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

2 September 2018

Cancer surveillance series: changing patterns of cutaneous malignant melanoma mortality rates among whites in the United States.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

2 September 2018

Selective anticancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF and RAS mutations in human lung cancer and melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of PTEN promotes tumor development in malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exclusion of BRAFV599E as a melanoma susceptibility mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent Trends in Cutaneous Melanoma Incidence Among Whites in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of BRAF(V599E) in human melanoma abrogates transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method of mutation analysis may contribute to discrepancies in reports of (V599E)BRAF mutation frequencies in melanocytic neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-06-0809

1 reference

Europe PubMed Central

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28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16912199%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16912199%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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