(Q36103287)

12 August 2017

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title

Oncogenic Ras in tumour progression and metastasis (English)

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12 August 2017

1 reference

Klaudia Giehl

1

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12 August 2017

1 March 2005

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12 August 2017

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12 August 2017

386

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12 August 2017

193-205

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12 August 2017

3

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Blocking oncogenic Ras signaling for cancer therapy

12 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras and Rho GTPases: a family reunion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ten years of protein kinase B signalling: a hard Akt to follow

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

PKB binding proteins. Getting in on the Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Oncogenic Ras and its role in tumor cell invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

GEFs: structural basis for their activation of small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Essential role for oncogenic Ras in tumour maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mechanisms of regulating the Raf kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Regulation of Raf-1 activation and signalling by dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

PI 3-kinase, Akt and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras interference as cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras and relatives--job sharing and networking keep an old family together

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Galectin-1 Augments Ras Activation and Diverts Ras Signals to Raf-1 at the Expense of Phosphoinositide 3-Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The importance of being K-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rho GTPases in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

PI3K/Akt and apoptosis: size matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Modelling the molecular circuitry of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Dislodgment and accelerated degradation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Distinct requirements for Ras oncogenesis in human versus mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras proteins: different signals from different locations

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras-effector interactions: after one decade

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Activation of the MAP kinase pathway by the protein kinase raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Genetic progression in the pancreatic ducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

MAP kinases and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Phospholipase C(epsilon): a novel Ras effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

21 January 2018

Signaling to Rho GTPases

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Regulation of cell motility by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

RAS inhibitors: potential for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Role of p120 Ras-GAP in directed cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Identification of AF-6 and canoe as putative targets for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

K-ras regulates the steady-state expression of matrix metalloproteinase 2 in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Tumor progression: Small GTPases and loss of cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Loss of RhoB expression in human lung cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rho GTPases control polarity, protrusion, and adhesion during cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cadherin engagement inhibits RhoA via p190RhoGAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cytoskeletal changes in cell transformation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cell migration: Rho GTPases lead the way

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

RAF/RAS oncogenes and mismatch-repair status

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rho family proteins: coordinating cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

21 January 2018

Rho proteins and cancer

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cell migration: integrating signals from front to back

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

21 January 2018

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Rho-like GTPases: their role in epithelial cell-cell adhesion and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Understanding Ras: 'it ain't over 'til it's over'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mechanisms of Ras protein targeting in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

AKT plays a central role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Regulation of transcription by MAP kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Identification of Nore1 as a potential Ras effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Signaling pathways in Ras-mediated tumorigenicity and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Phosphoinositide 3-kinases as targets for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Ras-dependent activation of the small GTPase Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Phosphoinositide 3-kinase signalling--which way to target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Oncogenic Ki-ras but not oncogenic Ha-ras blocks integrin beta1-chain maturation in colon epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Oncogenic c-Ki-ras but not oncogenic c-Ha-ras up-regulates CEA expression and disrupts basolateral polarity in colon epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Lipid-Regulated Kinases: Some Common Themes at Last

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

Prevalence of ras gene mutations in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.025

21 January 2018

Identifiers

DOI

10.1515/BC.2005.025

1 reference

12 August 2017

1 reference

PubMed ID

15843165