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Mechanisms of regulating the Raf kinase family
scientific article (publication date: May 2003)
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Europe PubMed Central
title
Mechanisms of regulating the Raf kinase family
(English)
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author name string
Huira Chong
series ordinal
1
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Haris G Vikis
series ordinal
2
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Kun-Liang Guan
series ordinal
3
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language of work or name
English
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publication date
May 2003
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published in
Cellular Signalling
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volume
15
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page(s)
463-9
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issue
5
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cites work
Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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inferred from DOI database lookup
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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The complexity of Raf-1 regulation
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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Mammalian Ras interacts directly with the serine/threonine kinase Raf
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7 January 2021
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inferred from DOI database lookup
Phosphorylation of Raf by ceramide-activated protein kinase
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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Phosphorylation and regulation of Raf by Akt (protein kinase B)
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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inferred from DOI database lookup
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice
1 reference
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7 January 2021
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The raf oncogene is associated with a radiation-resistant human laryngeal cancer
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer
1 reference
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences
1 reference
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Positive and negative regulation of Raf kinase activity and function by phosphorylation
1 reference
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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inferred from DOI database lookup
Autoregulation of the Raf-1 serine/threonine kinase
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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inferred from DOI database lookup
Mutational activation of c-raf-1 and definition of the minimal transforming sequence
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
MEK kinase activity is not necessary for Raf-1 function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
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inferred from DOI database lookup
ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
1 reference
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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Endothelial apoptosis in Braf-deficient mice
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 targets the protein kinase Raf-1 to mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isoform-specific localization of A-RAF in mitochondria
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras signalling on the endoplasmic reticulum and the Golgi
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of the Rho family GTPases in Ras-stimulated Raf activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the BRAF gene in human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C alpha activates RAF-1 by direct phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of c-Raf-1 by protein kinase A interferes with activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation by PKA of a site unique to B-Raf kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KSR, a novel protein kinase required for RAS signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinase suppressor of Ras is ceramide-activated protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinase suppressor of Ras signals through Thr269 of c-Raf-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KSR is a scaffold required for activation of the ERK/MAPK module
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical contribution of linker proteins to Raf kinase activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CNK, a RAF-binding multidomain protein required for RAS signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analysis of CNK in RAS signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spred is a Sprouty-related suppressor of Ras signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sprouty, an intracellular inhibitor of Ras signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0898-6568(02)00139-0
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2991382
OpenCitations bibliographic resource ID
2991382
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2991382
PubMed ID
12639709
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2991382
ResearchGate publication ID
10853333
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