(Q34311585)

1 August 2017

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title

Blocking oncogenic Ras signaling for cancer therapy (English)

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1 August 2017

Adjei AA

1

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1 August 2017

language of work or name

English

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publication date

1 July 2001

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Journal of the National Cancer Institute

1 August 2017

published in

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1 August 2017

volume

93

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1 August 2017

issue

14

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1 August 2017

page(s)

1062-1074

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https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

1 August 2017

1 reference

The ras protein family: evolutionary tree and role of conserved amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Ras‐effector interactions, the problem of specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Regulation of the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Enzymatic modification of proteins with a geranylgeranyl isoprenoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Friends and family: the role of the Rab GTPases in vesicular traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Regulation of the Ras signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Transgenic models of tumor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Ha-ras oncogenes are activated by somatic alterations in human urinary tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

RAS and leukemia: from basic mechanisms to gene-directed therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Bile induced acute oedematous pancreatitis in rats: non-parallel changes in pancreatic morphology and amylase release in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Implications and prognostic value of K-ras mutation for early-stage lung cancer in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The complexity of Raf-1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Mutational activation of c-raf-1 and definition of the minimal transforming sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Regulation of Ras-mediated signalling: more than one way to skin a cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Structure and biological activity of human homologs of the raf/mil oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

PI3K: downstream AKTion blocks apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

eIF4E activity is regulated at multiple levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The regulation of AP-1 activity by mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

R-Ras is regulated by activators and effectors distinct from those that control Ras function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Multiple ras effector pathways contribute to G(1) cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The gamma subunit of transducin is farnesylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Characterization of HDJ-2, a human 40 kD heat shock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

Prevalence of ras gene mutations in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F93.14.1062

21 January 2018

Identifiers

DOI

10.1093/JNCI/93.14.1062

1 reference

1 August 2017

1 reference