(Q40831741)

24 September 2017

title

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli (English)

1 reference

24 September 2017

3

H L Moses

1 reference

24 September 2017

B K Law

1

1 reference

24 September 2017

P Norgaard

series ordinal

2

1 reference

24 September 2017

language of work or name

English

0 references

publication date

1 April 2000

1 reference

Journal of Biological Chemistry

24 September 2017

published in

1 reference

24 September 2017

volume

275

1 reference

24 September 2017

issue

15

1 reference

24 September 2017

page(s)

10796-10801

1 reference

Function and regulation of ras.

24 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

TOR controls translation initiation and early G1 progression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Atypical protein kinase Clambda binds and regulates p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Structural and functional analysis of pp70S6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

p70s6k function is essential for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

From bench top to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.15.10796

21 January 2018

Identifiers

DOI

10.1074/JBC.275.15.10796

1 reference

24 September 2017

1 reference