(Q40871227)

English

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

scientific article published on June 2000

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Europe PubMed Central

PubMed publication ID

24 September 2017

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

pancreatic carcinoma

1 reference

based on heuristic

inferred from title

author name string

Giehl K

1

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Skripczynski B

2

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Mansard A

3

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Menke A

4

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Gierschik P

5

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

language of work or name

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publication date

1 June 2000

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

2930-2942

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Signaling mechanisms in growth factor-stimulated cell motility

1 reference

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Raf meets Ras: completing the framework of a signal transduction pathway

1 reference

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Proteins regulating Ras and its relatives

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Structure and biological activity of human homologs of the raf/mil oncogene

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Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations

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Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

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Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

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Essential role for oncogenic Ras in tumour maintenance

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Analysis of Ras protein expression in mammalian cells

1 reference

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Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

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Ras signalling and apoptosis

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

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Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor

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Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors

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Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors

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Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

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Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

1 reference

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Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

1 reference

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

1 reference

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Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

1 reference

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Oncoprotein Signalling and Mitosis

1 reference

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Establishment of a continuous tumor-cell line (PANC-1) from a human carcinoma of the exocrine pancreas

1 reference

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Function and regulation of ras.

1 reference

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21 January 2018

1 reference

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Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

1 reference

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21 January 2018

Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6.

1 reference

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21 January 2018

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

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Early signals in the mitogenic response

1 reference

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Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

1 reference

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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1 reference

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Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

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Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle

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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

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Characterization of a new primary human pancreatic tumor line.

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Regulation of transcription by MAP kinase cascades

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Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts

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An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells

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21 January 2018

Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation

1 reference

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7 January 2021

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

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7 January 2021

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Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

1 reference

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inferred from DOI database lookup

K-ras modulates the cell cycle via both positive and negative regulatory pathways

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Measuring activation of kinases in mitogen-activated protein kinase regulatory network

1 reference

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Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes

1 reference

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K-ras is essential for the development of the mouse embryo

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What is the true rate of K-ras mutation in carcinoma of the pancreas?

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Pancreatic cancer: medical aspects

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Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

1 reference

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The MAPK signaling cascade

1 reference

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Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations

1 reference

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Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation

1 reference

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Epidermal growth factor receptor-mediated motility in fibroblasts

1 reference

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Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

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Identifiers

10.1038/SJ.ONC.1203612

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

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