(Q37427295)

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Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease

scientific article published on 17 December 2013

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scholarly article

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Europe PubMed Central

20 August 2017

Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease (English)

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Europe PubMed Central

20 August 2017

Alzheimer's disease

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frontotemporal lobar degeneration

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based on heuristic

inferred from title

8

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11 June 2020

author name string

Shuk Wai Ho

1

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11 June 2020

Yuk Tung Chanel Tsui

2

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11 June 2020

Ting Ting Wong

3

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11 June 2020

Stanley Kwok-Kuen Cheung

4

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11 June 2020

William B Goggins

5

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11 June 2020

Lau Ming Yi

6

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11 June 2020

Kwok Kin Cheng

7

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11 June 2020

publication date

17 December 2013

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Translational Neurodegeneration

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11 June 2020

2

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11 June 2020

1

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11 June 2020

24

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11 June 2020

https://scigraph.springernature.com/pub.10.1186/2047-9158-2-24

0 references

Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases

1 reference

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23 August 2017

Highly stabilized curcumin nanoparticles tested in an in vitro blood-brain barrier model and in Alzheimer's disease Tg2576 mice

1 reference

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23 August 2017

Alzheimer's disease: recent advances and future perspectives

1 reference

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23 August 2017

Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease

1 reference

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Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

1 reference

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Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease

1 reference

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The Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain

1 reference

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23 August 2017

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

1 reference

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

1 reference

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Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system

1 reference

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23 August 2017

Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones

1 reference

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23 August 2017

Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes.

1 reference

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23 August 2017

Development and application of Hsp90 inhibitors

1 reference

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23 August 2017

Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

1 reference

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23 August 2017

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

1 reference

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23 August 2017

A decade of tau transgenic animal models and beyond

1 reference

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23 August 2017

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

1 reference

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23 August 2017

Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).

1 reference

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23 August 2017

Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein

1 reference

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Gonadal hormone modulation of hippocampal neurogenesis in the adult

1 reference

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23 August 2017

Sex, hormones, and Alzheimer's disease

1 reference

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23 August 2017

Transgenic animal models of tauopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878847

23 August 2017

What is a co-chaperone?

1 reference

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23 August 2017

Heat shock protein 90 as a molecular target for cancer therapeutics

1 reference

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23 August 2017

Estrogen can protect neurons: modes of action

1 reference

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23 August 2017

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

1 reference

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23 August 2017

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

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23 August 2017

Estrogens: trophic and protective factors in the adult brain

1 reference

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23 August 2017

Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 In vivo

1 reference

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23 August 2017

Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset

1 reference

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23 August 2017

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

1 reference

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23 August 2017

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1 reference

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23 August 2017

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

1 reference

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23 August 2017

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

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23 August 2017

Quantitation and intracellular localization of the 85K heat shock protein by using monoclonal and polyclonal antibodies

1 reference

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23 August 2017

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

1 reference

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

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6 September 2017

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1 reference

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14 September 2017

Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line

1 reference

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14 September 2017

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

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14 September 2017

Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease

1 reference

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14 September 2017

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1 reference

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Chemical manipulation of hsp70 ATPase activity regulates tau stability.

1 reference

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1 reference

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Heat shock protein 90 indirectly regulates ERK activity by affecting Raf protein metabolism

1 reference

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26 June 2018

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878847

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1 reference

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26 June 2018

Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878847

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In vitro amyloid aggregate forming ability of TGFBI mutants that cause corneal dystrophies

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2 September 2018

Heart complications in familial transthyretin amyloidosis: impact of age and gender.

1 reference

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2 September 2018

Amyloid oligomers in diabetic and nondiabetic human pancreas

1 reference

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Higher islet amyloid load in men than in women with type 2 diabetes mellitus.

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Gender-related risk of myocardial involvement in systemic amyloidosis.

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Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

1 reference

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1 reference

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1 reference

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Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice.

1 reference

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A TOXICOLOGIC STUDY OF DIMETHYL SULFOXIDE.

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Staining methods for identification of amyloid in tissue

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Counting plaques and tangles in Alzheimer's disease: concordance of technicians and pathologists.

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2 September 2018

Identifiers

10.1186/2047-9158-2-24

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11 June 2020

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11 June 2020

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11 June 2020

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