(Q40374915)

19 September 2017

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration (English)

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19 September 2017

2

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19 September 2017

9

Gen Sobue

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19 September 2017

Masahiro Waza

1

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19 September 2017

Masahisa Katsuno

3

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19 September 2017

Makoto Minamiyama

4

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19 September 2017

Chen Sang

5

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19 September 2017

Fumiaki Tanaka

6

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19 September 2017

Akira Inukai

7

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19 September 2017

Manabu Doyu

8

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19 September 2017

language of work or name

English

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publication date

11 September 2005

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19 September 2017

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19 September 2017

11

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19 September 2017

1088-1095

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19 September 2017

10

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https://scigraph.springernature.com/pub.10.1038/nm1298

19 September 2017

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cites work

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

1 reference

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

21 January 2018

1 reference

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

p23, a simple protein with complex activities

21 January 2018

1 reference

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

21 January 2018

1 reference

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

21 January 2018

1 reference

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

21 January 2018

1 reference

Effect of geldanamycin on androgen receptor function and stability

21 January 2018

1 reference

Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

21 January 2018

1 reference

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

1 reference

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

1 reference

The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

21 January 2018

1 reference

Modulation of neurodegeneration by molecular chaperones

21 January 2018

1 reference

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

1 reference

Chaperones increase association of tau protein with microtubules

21 January 2018

1 reference

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

21 January 2018

1 reference

Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

21 January 2018

1 reference

Glutamine repeats and neurodegeneration

21 January 2018

1 reference

Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene

21 January 2018

1 reference

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

21 January 2018

1 reference

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

21 January 2018

1 reference

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

21 January 2018

1 reference

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

21 January 2018

1 reference

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

21 January 2018

1 reference

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

1 reference

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

21 January 2018

1 reference

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

1 reference

7 January 2021

Nucleotides and two functional states of hsp90

1 reference

7 January 2021

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

1 reference

7 January 2021

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

1 reference

7 January 2021

Founder effect in spinal and bulbar muscular atrophy (SBMA)

1 reference

7 January 2021

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

7 January 2021

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1298

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Dimensions Publication ID

19 September 2017

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