(Q73174347)

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Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

scientific article published on 01 March 2003

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12657679%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12657679%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

muscular atrophy

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1

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1 November 2019

11

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Gen Sobue

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1 November 2019

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Masahisa Katsuno

2

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1 November 2019

Makoto Minamiyama

3

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1 November 2019

Chen Sang

4

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1 November 2019

Gerassimos Pagoulatos

5

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1 November 2019

Charalampos Angelidis

6

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1 November 2019

Moriaki Kusakabe

7

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1 November 2019

Atsushi Yoshiki

8

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1 November 2019

Yasushi Kobayashi

9

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1 November 2019

Manabu Doyu

10

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1 November 2019

publication date

1 March 2003

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1 November 2019

Journal of Neuroscience

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1 November 2019

23

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1 November 2019

6

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1 November 2019

2203-2211

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12657679%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific somatic mosaicism in spinal and bulbar muscular atrophy is dependent on CAG-repeat length and androgen receptor--gene expression level.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine repeats and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB-binding protein sequestration by expanded polyglutamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of genes that modify ataxin-1-induced neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hiroshi Kawahara (1858-1918).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of chaperones on polyglutamine diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of chaperones in polyglutamine disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meiotic stability and genotype-phenotype correlation of the trinucleotide repeat in X-linked spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A huntingtin-associated protein enriched in brain with implications for pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular chaperone functions of heat-shock proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in human spinal ventral horn cells with special reference to the loss of small neurons in the intermediate zone: a quantitative analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Founder effect in spinal and bulbar muscular atrophy (SBMA)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Hsp70 and Hsp60 chaperone machines

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/12657679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-06-02203.2003

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12657679%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12657679%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12657679%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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