(Q35990274)

11 August 2017

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title

Modulation of neurodegeneration by molecular chaperones (English)

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11 August 2017

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Paul J Muchowski

1

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PubMed ID

15611723

11 August 2017

Jennifer L Wacker

series ordinal

2

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PubMed ID

15611723

11 August 2017

language of work or name

English

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publication date

1 January 2005

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Nature Reviews Neuroscience

11 August 2017

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11 August 2017

6

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11 August 2017

11-22

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11 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrn1587

11 August 2017

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cites work

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Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

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CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

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The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

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Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

31 March 2020

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Polyglutamine protein aggregates are dynamic

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Chaperones increase association of tau protein with microtubules

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

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CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

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Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

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TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

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Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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Pharmacological prevention of Parkinson disease in Drosophila.

31 March 2020

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Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

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High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

31 March 2020

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The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity

31 March 2020

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Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain

31 March 2020

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Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

31 March 2020

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Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

31 March 2020

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Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1.

31 March 2020

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Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

31 March 2020

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

31 March 2020

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Protective effect of chaperones on polyglutamine diseases

31 March 2020

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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

31 March 2020

1 reference

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

31 March 2020

1 reference

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

31 March 2020

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Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

31 March 2020

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

31 March 2020

1 reference

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

31 March 2020

1 reference

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

31 March 2020

1 reference

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

31 March 2020

1 reference

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

31 March 2020

1 reference

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

31 March 2020

1 reference

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

31 March 2020

1 reference

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

31 March 2020

1 reference

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

31 March 2020

1 reference

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

31 March 2020

1 reference

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

31 March 2020

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Identification of genes that modify ataxin-1-induced neurodegeneration.

31 March 2020

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Genetic suppression of polyglutamine toxicity in Drosophila

31 March 2020

1 reference

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

31 March 2020

1 reference

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

31 March 2020

1 reference

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

31 March 2020

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Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

31 March 2020

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Mechanism of prion propagation: amyloid growth occurs by monomer addition

31 March 2020

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The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro

31 March 2020

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A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation

31 March 2020

1 reference

Trehalose accumulates in Saccharomyces cerevisiae during exposure to agents that induce heat shock response

31 March 2020

1 reference

Multiple effects of trehalose on protein folding in vitro and in vivo

31 March 2020

1 reference

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

31 March 2020

1 reference

Molecular chaperones and the stress of oncogenesis.

31 March 2020

1 reference

Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

31 March 2020

1 reference

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

31 March 2020

1 reference

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

31 March 2020

1 reference

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

31 March 2020

1 reference

Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1

31 March 2020

1 reference

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

31 March 2020

1 reference

HSP104 required for induced thermotolerance

31 March 2020

1 reference

Heat-shock protein 104 expression is sufficient for thermotolerance in yeast

31 March 2020

1 reference

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

31 March 2020

1 reference

Chaperones and transcriptional regulation by nuclear receptors

31 March 2020

1 reference

The Hsp70 and Hsp60 chaperone machines

31 March 2020

1 reference

A hitchhiker's guide to the human Hsp70 family

31 March 2020

1 reference

Chaperone-mediated protein folding

31 March 2020

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The conserved G/F motif of the DnaJ chaperone is necessary for the activation of the substrate binding properties of the DnaK chaperone

31 March 2020

1 reference

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

31 March 2020

1 reference

Molecular chaperones in cellular protein folding

31 March 2020

1 reference

Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function

31 March 2020

1 reference

Alpha-crystallin can function as a molecular chaperone

31 March 2020

1 reference

Small heat-shock proteins and their potential role in human disease

31 March 2020

1 reference

Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA

31 March 2020

1 reference

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

31 March 2020

1 reference

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

31 March 2020

1 reference

Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

31 March 2020

1 reference

Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60

31 March 2020

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Roles of molecular chaperones in protein misfolding diseases

31 March 2020

1 reference

Expression of heat shock proteins in Alzheimer's disease

31 March 2020

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Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.

31 March 2020

1 reference

Expression of small heat-shock protein hsp 27 in reactive gliosis in Alzheimer disease and other types of dementia.

31 March 2020

1 reference

Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles

31 March 2020

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Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

31 March 2020

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN1587

1 reference

11 August 2017

1 reference

PubMed ID

15611723