(Q37427485)

20 August 2017

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title

Wnt signaling in bone metabolism (English)

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20 August 2017

Takuo Kubota

1

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PubMed ID

19333681

20 August 2017

Toshimi Michigami

series ordinal

2

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PubMed ID

19333681

20 August 2017

Keiichi Ozono

series ordinal

3

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20 August 2017

31 March 2009

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Journal of Bone and Mineral Metabolism

20 August 2017

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20 August 2017

27

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20 August 2017

3

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20 August 2017

265-271

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https://scigraph.springernature.com/pub.10.1007/s00774-009-0064-8

20 August 2017

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The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

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12 December 2020

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

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Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

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12 December 2020

The osteocyte lineage

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12 December 2020

Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix

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PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells

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Regulation of osteoblastogenesis and bone mass by Wnt10b

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Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

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12 December 2020

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

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12 December 2020

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

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12 December 2020

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12 December 2020

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

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An LDL-receptor-related protein mediates Wnt signalling in mice

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12 December 2020

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

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The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

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12 December 2020

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

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12 December 2020

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

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12 December 2020

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

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12 December 2020

Clinical and molecular findings in osteoporosis-pseudoglioma syndrome

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12 December 2020

Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

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12 December 2020

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

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12 December 2020

High bone density due to a mutation in LDL-receptor-related protein 5

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12 December 2020

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

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12 December 2020

Osteocytes, mechanosensing and Wnt signaling

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12 December 2020

High bone mass in mice expressing a mutant LRP5 gene

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12 December 2020

Wnt signaling and skeletal development

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12 December 2020

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12 December 2020

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

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12 December 2020

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12 December 2020

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

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12 December 2020

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12 December 2020

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12 December 2020

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

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12 December 2020

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12 December 2020

GSK-3beta controls osteogenesis through regulating Runx2 activity

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12 December 2020

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12 December 2020

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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12 December 2020

Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma

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12 December 2020

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

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12 December 2020

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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12 December 2020

The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes

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12 December 2020

Wnt/beta-catenin signaling in development and disease

1 reference

12 December 2020

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 reference

12 December 2020

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

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12 December 2020

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.

1 reference

12 December 2020

Essential role of beta-catenin in postnatal bone acquisition

1 reference

12 December 2020

1 reference

12 December 2020

Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro

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12 December 2020

10.1007/S00774-009-0064-8

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19333681