(Q37430834)

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Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage.

scientific article published on 08 September 2009

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19738038%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19738038%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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apoptotic process

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Gordon P Meares

3

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7 February 2020

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Katherine J Hughes

1

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7 February 2020

Kari T Chambers

2

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7 February 2020

John A Corbett

4

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7 February 2020

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8 September 2009

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7 February 2020

American Journal of Physiology - Endocrinology and Metabolism

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7 February 2020

297

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7 February 2020

5

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Europe PubMed Central

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7 February 2020

E1187-96

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Europe PubMed Central

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7 February 2020

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

1 reference

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23 August 2017

Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

p53 in recombination and repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Necrotic death as a cell fate

1 reference

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23 August 2017

Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1

1 reference

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23 August 2017

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

The intimate relation between nitric oxide and superoxide in apoptosis and cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Apoptotic signal transduction pathways in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Nitric oxide inhibition of mitochondrial respiration and its role in cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Potential role of PKR in double-stranded RNA-induced macrophage activation

1 reference

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23 August 2017

Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

A simple technique for quantitation of low levels of DNA damage in individual cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Electrophysiology of stimulus-secretion coupling in human beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

23 August 2017

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

14 September 2017

Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

14 September 2017

Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

14 September 2017

Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

28 September 2017

The role of interleukin-1 in the pathogenesis of IDDM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

28 September 2017

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

28 September 2017

The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

28 September 2017

Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

28 September 2017

Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Endogenous nitric oxide induced by interleukin-1 beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Interleukin‐1 ‐induced expression of nitric oxide synthase in insulin‐producing cells is preceded by c‐fos induction and depends on gene transcription and protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Interleukin 1 is potent modulator of insulin secretion from isolated rat islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

26 June 2018

Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

2 September 2018

Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

2 September 2018

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

2 September 2018

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781357

2 September 2018

A cross-platform public domain PC image-analysis program for the comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of islets of Langerhans from rodent pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologic anatomy of the pancreas in juvenile diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines cause functional and structural damage to isolated islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of human IL-1 by LIF induction, pancreatic islet-cell cytotoxicity, and bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric Oxide Inhibits Caspase-3 byS-Nitrosationin Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19738038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPENDO.00214.2009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19738038%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19738038%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19738038%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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