(Q37441564)

English

Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone.

scientific article published on 13 October 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19825997%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone (English)

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19825997%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

5

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9 February 2020

author name string

Jennifer L Gilmore

1

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9 February 2020

Ryan M Gonterman

2

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9 February 2020

Keshav Menon

3

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9 February 2020

Gwendolen Lorch

4

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9 February 2020

Alex Robling

6

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9 February 2020

John Foley

7

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9 February 2020

publication date

13 October 2009

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9 February 2020

Molecular Cancer Research

1 reference

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9 February 2020

7

1 reference

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9 February 2020

10

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9 February 2020

1714-1728

1 reference

Europe PubMed Central

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9 February 2020

Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Amphiregulin as a novel target for breast cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate

1 reference

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23 August 2017

Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer

1 reference

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23 August 2017

Molecular biology of bone metastasis

1 reference

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Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer

1 reference

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23 August 2017

Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Lung cancer: diagnosis and management.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

PTHrP gene expression in cancer: do all paths lead to Ets?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

The calcium-sensing receptor in normal physiology and pathophysiology: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

EGFR signal transactivation in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Epidermal growth factor receptor family in lung cancer and premalignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Cancer and bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Alternative promoter usage and mRNA splicing pathways for parathyroid hormone-related protein in normal tissues and tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Human squamous cell lung cancers express increased epidermal growth factor receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Parathyroid hormone-related protein purified from a human lung cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

23 August 2017

Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

6 September 2017

A novel lung cancer signature mediates metastatic bone colonization by a dual mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

14 September 2017

Activation of a nuclear factor kappaB/interleukin-1 positive feedback loop by amphiregulin in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

14 September 2017

Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases

1 reference

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14 September 2017

Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration

1 reference

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14 September 2017

Chemokines induce matrix metalloproteinase-2 through activation of epidermal growth factor receptor in arterial smooth muscle cells

1 reference

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1 reference

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SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells

1 reference

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14 September 2017

Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

14 September 2017

The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells

1 reference

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Human Airway Trypsin-Like Protease Increases Mucin Gene Expression in Airway Epithelial Cells

1 reference

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Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone

1 reference

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14 September 2017

The biology of non-small cell lung cancer

1 reference

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14 September 2017

ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation.

1 reference

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Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

28 September 2017

The noncalcemic vitamin D analogs EB1089 and 22-oxacalcitriol suppress serum-induced parathyroid hormone-related peptide gene expression in a lung cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784013

28 September 2017

Physiological and pathological roles of parathyroid hormone-related peptide

1 reference

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28 September 2017

An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis.

1 reference

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26 June 2018

The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro

1 reference

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26 June 2018

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

1 reference

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26 June 2018

Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer

1 reference

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26 June 2018

Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes

1 reference

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1 reference

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Low molecular weight inhibitors in corneal ulceration

1 reference

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2 September 2018

Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-18 inhibits osteolytic bone metastasis by human lung cancer cells possibly through suppression of osteoclastic bone-resorption in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19825997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1541-7786.MCR-09-0131

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19825997%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19825997%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19825997%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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