(Q37463774)

English

Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in altered thymocyte development

scientific article published on 08 October 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in altered thymocyte development (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

based on heuristic

inferred from title

0 references

author name string

Miranda L Hanson

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Kathleen M Brundage

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Rosana Schafer

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Janet C Tou

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

John B Barnett

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

publication date

8 October 2009

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Toxicology and Applied Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

242

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

136-145

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2789900/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

A dedicated Wnt secretion factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Four-dimensional imaging and quantification of gene expression in early developing zebrafish (Danio rerio) embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Reduced thymocyte development in sonic hedgehog knockout embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Wnt proteins are lipid-modified and can act as stem cell growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Patched acts catalytically to suppress the activity of Smoothened

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Hedgehog signaling in animal development: paradigms and principles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Signaling through beta-catenin and Lef/Tcf

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Role of members of the Wnt gene family in human hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Identification of a palmitic acid-modified form of human Sonic hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Biochemical evidence that patched is the Hedgehog receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Dual roles for patched in sequestering and transducing Hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Functional interaction of beta-catenin with the transcription factor LEF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

The oncogene jun and nuclear signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

23 August 2017

Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

14 September 2017

A freely diffusible form of Sonic hedgehog mediates long-range signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

28 September 2017

Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

28 September 2017

Differential sensitivity of the SWV and C57BL/6 mouse strains to the teratogenic action of single administrations of cadmium given throughout the period of anterior neuropore closure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

Toxicokinetics and biochemistry of cadmium with special emphasis on the role of metallothionein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

Induction of c-fos proto-oncogene in mesangial cells by cadmium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

Cd(2+)-induced c-myc mRNA accumulation in NRK-49F cells is blocked by the protein kinase inhibitor H7 but not by HA1004, indicating that protein kinase C is a mediator of the response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

Cadmium-induced expression of immediate early genes in LLC-PK1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

Immunopathology of chronic cadmium administration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

26 June 2018

Adherens junction breakdown in the periderm following cadmium administration in the chick embryo: distribution of cadherins and associated molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Cadmium causes delayed effects on renal function in the offspring of cadmium-contaminated pregnant female rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Sensorimotor developmental delays and lower anxiety in rats prenatally exposed to cadmium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Cadmium-induced postaxial forelimb ectrodactyly: association with altered sonic hedgehog signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

beta-Catenin expression enhances generation of mature thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Kinetics of thymocyte developmental process in fetal and neonatal mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Thymic epithelial cells provide WNT signals to developing thymocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Developmental toxicity of cadmium in mice. II. Immunotoxic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789900

2 September 2018

Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice: 2. Relationship to the number of circulating blood cells and haemopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An HMG-box-containing T-cell factor required for thymocyte differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medical management guidelines for unidentified chemicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of cadmium in T lymphocyte subsets and cytokine expression: differential regulation by oxidative stress and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistence of stored Cd 2+ in the livers and kidneys of female rats during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Biological aspects of occupational exposure to cadmium and several other metals]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in immunological susceptibility to cadmium toxicity between two rat strains as demonstrated with cell biological methods. Effect of cadmium on DNA synthesis of thymus lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical involvement of Tcf-1 in expansion of thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lung cancer and exposure to environmental cadmium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19818801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.TAAP.2009.09.023

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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