(Q37464743)

20 August 2017

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title

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials (English)

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20 August 2017

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4

Ann Marie Schmidt

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20 August 2017

Nigel A Calcutt

1

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20 August 2017

Mark E Cooper

series ordinal

2

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20 August 2017

Tim S Kern

series ordinal

3

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20 August 2017

publication date

1 May 2009

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Nature Reviews Drug Discovery

20 August 2017

published in

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20 August 2017

volume

8

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20 August 2017

issue

5

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20 August 2017

page(s)

417-429

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Diabetes mellitus in children and adolescents

20 August 2017

cites work

1 reference

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Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

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Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus

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10-year follow-up of intensive glucose control in type 2 diabetes

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Long-term follow-up after tight control of blood pressure in type 2 diabetes.

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Chronic vascular inflammation in patients with type 2 diabetes: endothelial biopsy and RT-PCR analysis.

31 March 2020

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Microcirculation and oxidative stress

31 March 2020

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Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic Vasculopathy

31 March 2020

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Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures

31 March 2020

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Alteration of the blood-retinal barrier in experimental diabetes mellitus

31 March 2020

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Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol

31 March 2020

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Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

31 March 2020

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Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions

31 March 2020

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Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.

31 March 2020

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Central role for aldose reductase pathway in myocardial ischemic injury

31 March 2020

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Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice

31 March 2020

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Recipes for creating animal models of diabetic cardiovascular disease

31 March 2020

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Diabetes-induced accelerated atherosclerosis in swine

31 March 2020

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Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

31 March 2020

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Endothelial cell activation in patients with decompensated heart failure

31 March 2020

1 reference

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

31 March 2020

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Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group

31 March 2020

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

31 March 2020

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Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

31 March 2020

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Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy

31 March 2020

1 reference

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.

31 March 2020

1 reference

Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications

31 March 2020

1 reference

Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress

31 March 2020

1 reference

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice

31 March 2020

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Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes

31 March 2020

1 reference

Recent studies of aldose reductase enzyme inhibition for diabetic complications

31 March 2020

1 reference

Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications

31 March 2020

1 reference

Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin

31 March 2020

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Improved arterial compliance by a novel advanced glycation end-product crosslink breaker

31 March 2020

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Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.

31 March 2020

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Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes

31 March 2020

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Antagonism of RAGE suppresses peripheral nerve regeneration

31 March 2020

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RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways

31 March 2020

1 reference

Statins for diabetic cardiovascular complications

31 March 2020

1 reference

Effects of PPAR gamma agonists on cardiovascular function in obese, non-diabetic patients

31 March 2020

1 reference

Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects

31 March 2020

1 reference

Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in diabetes patients with Cardiovascular History (APPROACH): study design and baseline characteristics

31 March 2020

1 reference

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

31 March 2020

1 reference

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

31 March 2020

1 reference

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

31 March 2020

1 reference

Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.

31 March 2020

1 reference

Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus

31 March 2020

1 reference

Effects of intensive glucose lowering in type 2 diabetes

31 March 2020

1 reference

Images in clinical medicine. Paget's disease of the mandible

31 March 2020

1 reference

Clinical review: The role of advanced glycation end products in progression and complications of diabetes

31 March 2020

1 reference

UKPDS and the legacy effect.

31 March 2020

1 reference

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

31 March 2020

1 reference

An epigenetic clue to diabetic vascular disease

31 March 2020

1 reference

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

31 March 2020

1 reference

Effect of a multifactorial intervention on mortality in type 2 diabetes

31 March 2020

1 reference

Projecting the number of patients with end-stage renal disease in the United States to the year 2015

31 March 2020

1 reference

The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy

31 March 2020

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Diabetic management in patients with renal failure.

31 March 2020

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Pathogenesis, prevention, and treatment of diabetic nephropathy

31 March 2020

1 reference

How long should insulin be used once a vial is started?

31 March 2020

1 reference

Aliskiren combined with losartan in type 2 diabetes and nephropathy

31 March 2020

1 reference

ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes

31 March 2020

1 reference

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase

31 March 2020

1 reference

Mouse models of diabetic nephropathy

31 March 2020

1 reference

Impact of genetic background on nephropathy in diabetic mice

31 March 2020

1 reference

Development of late-stage diabetic nephropathy in OVE26 diabetic mice

31 March 2020

1 reference

Structural-functional relationships in diabetic nephropathy

31 March 2020

1 reference

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

31 March 2020

1 reference

RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy

31 March 2020

1 reference

Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy

31 March 2020

1 reference

Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice

31 March 2020

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Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice

31 March 2020

1 reference

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

31 March 2020

1 reference

Interactions between renin angiotensin system and advanced glycation in the kidney.

31 March 2020

1 reference

Role of advanced glycation end products in diabetic nephropathy.

31 March 2020

1 reference

The effect of ruboxistaurin on nephropathy in type 2 diabetes

31 March 2020

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Mechanisms of kidney fibrosis and the role of antifibrotic therapies

31 March 2020

1 reference

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

31 March 2020

1 reference

Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

31 March 2020

1 reference

The future of clinical trials in chronic renal disease: outcome of an NIH/FDA/Physician Specialist Conference. Evaluation of Clinical Trial Endpoints in Chronic Renal Disease Study Group

31 March 2020

1 reference

Nonalbuminuric renal insufficiency in type 2 diabetes.

31 March 2020

1 reference

Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy

31 March 2020

1 reference

31 March 2020

1 reference

The prevalence of diabetic retinopathy among adult type 1 diabetic persons in the United States

31 March 2020

1 reference

The prevalence of diabetic retinopathy among adults in the United States

31 March 2020

1 reference

Animal models of oxygen-induced retinopathy

31 March 2020

1 reference

Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment

31 March 2020

1 reference

Characterisation of a model for retinal neovascularisation. VEGF model characterisation

31 March 2020

1 reference

Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

31 March 2020

1 reference

Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin

31 March 2020

1 reference

The Ins2Akita mouse as a model of early retinal complications in diabetes

31 March 2020

1 reference

Progression of incipient diabetic retinopathy during good glycemic control.

31 March 2020

1 reference

A mouse model of diabetic retinopathy

31 March 2020

1 reference

Experimental Galactosemia Produces Diabetic-like Retinopathy

31 March 2020

1 reference

The RAGE axis in early diabetic retinopathy

31 March 2020

1 reference

Ocular neovascularization: basic mechanisms and therapeutic advances

31 March 2020

1 reference

Immunological mechanisms in the pathogenesis of diabetic retinopathy

31 March 2020

1 reference

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

31 March 2020

1 reference

Laser treatment in diabetic retinopathy

31 March 2020

1 reference

The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes: transgenic and interventional studies

31 March 2020

1 reference

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

31 March 2020

1 reference

Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial

31 March 2020

1 reference

Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema.

31 March 2020

1 reference

Triple therapy of vitrectomy, intravitreal triamcinolone, and macular laser photocoagulation for intractable diabetic macular edema

31 March 2020

1 reference

The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized cl

31 March 2020

1 reference

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

31 March 2020

1 reference

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

31 March 2020

1 reference

Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema

31 March 2020

1 reference

Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (macugen) in diabetic retinopathy

31 March 2020

1 reference

Three-dimensional optical coherence tomography of proliferative diabetic retinopathy

31 March 2020

1 reference

Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid

31 March 2020

1 reference

Early supernormal retinal oxygenation response in patients with diabetes

31 March 2020

1 reference

Early Involvement of the Spinal Cord in Diabetic Peripheral Neuropathy

31 March 2020

1 reference

Microvascular disease in type 1 diabetes alters brain activation: a functional magnetic resonance imaging study

31 March 2020

1 reference

Peripheral nerve structure and function in experimental diabetes

31 March 2020

1 reference

Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model

31 March 2020

1 reference

Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats

31 March 2020

1 reference

Erythropoietin both protects from and reverses experimental diabetic neuropathy

31 March 2020

1 reference

Noninvasive monitoring of diabetes-induced cutaneous nerve fiber loss and hypoalgesia in thy1-YFP transgenic mice

31 March 2020

1 reference

Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs

31 March 2020

1 reference

Corneal sensitivity in dogs with diabetes mellitus

31 March 2020

1 reference

Nerve pathology in the type 1 diabetic dog: effects of treatment with sulindac

31 March 2020

1 reference

Differential hypertrophy and atrophy among all types of cutaneous innervation in the glabrous skin of the monkey hand during aging and naturally occurring type 2 diabetes

31 March 2020

1 reference

Endoneurial microvascular pathology in feline diabetic neuropathy

31 March 2020

1 reference

Comparable myelinated nerve pathology in feline and human diabetes mellitus

31 March 2020

1 reference

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy.

31 March 2020

1 reference

Diabetic neuropathy and oxidative stress

31 March 2020

1 reference

RAGE, diabetes, and the nervous system

31 March 2020

1 reference

Growth factors as therapeutics for diabetic neuropathy.

31 March 2020

1 reference

31 March 2020

Glucose neurotoxicity

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Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats

31 March 2020

1 reference

Neurotrophin-3-induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: involvement of the polyol pathway

31 March 2020

1 reference

Protection of sensory function in diabetic rats by Neotrofin

31 March 2020

1 reference

A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats

31 March 2020

1 reference

Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals

31 March 2020

1 reference

Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse

31 March 2020

1 reference

HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy

31 March 2020

1 reference

Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats

31 March 2020

1 reference

Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies

31 March 2020

1 reference

HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy

31 March 2020

1 reference

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

31 March 2020

1 reference

Insulin receptor in rat peripheral nerve: its localization and alternatively spliced isoforms

31 March 2020

1 reference

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.

31 March 2020

1 reference

The effect of low-dose insulin on mechanical sensitivity and allodynia in type I diabetes neuropathy

31 March 2020

1 reference

Direct insulin signaling of neurons reverses diabetic neuropathy

31 March 2020

1 reference

Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy

31 March 2020

1 reference

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease

31 March 2020

1 reference

Alzheimer-like changes in rat models of spontaneous diabetes

31 March 2020

1 reference

The pathological interaction between diabetes and presymptomatic Alzheimer's disease

31 March 2020

1 reference

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin

31 March 2020

1 reference

Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review.

31 March 2020

1 reference

Common pathological processes in Alzheimer disease and type 2 diabetes: a review

31 March 2020

1 reference

EFNS guidelines on pharmacological treatment of neuropathic pain.

31 March 2020

1 reference

Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials

31 March 2020

1 reference

Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens

31 March 2020

1 reference

A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain

31 March 2020

1 reference

Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatients

31 March 2020

1 reference

Changes of sodium channel expression in experimental painful diabetic neuropathy

31 March 2020

1 reference

Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

31 March 2020

1 reference

Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats

31 March 2020

1 reference

Pathogenesis of spinally mediated hyperalgesia in diabetes.

31 March 2020

1 reference

Value of repeated measures of nerve conduction and quantitative sensory testing in a diabetic neuropathy trial

31 March 2020

1 reference

Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group

31 March 2020

1 reference

EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy

31 March 2020

1 reference

Skin biopsy as a diagnostic tool in peripheral neuropathy.

31 March 2020

1 reference

Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy

31 March 2020

1 reference

Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients

31 March 2020

1 reference

Surrogate markers of small fiber damage in human diabetic neuropathy.

31 March 2020

1 reference

Corneal Confocal Microscopy Detects Early Nerve Regeneration After Pancreas Transplantation in Patients With Type 1 Diabetes

31 March 2020

1 reference

Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus

31 March 2020

1 reference

Immunohistochemical localization of aldose reductase. II. Rat eye and kidney

31 March 2020

1 reference

Immunohistochemical localization of aldose reductase. I. Enzyme purification and antibody preparation--localization in peripheral nerve, artery, and testis

31 March 2020

1 reference

Upregulation of RAGE and its ligands in proliferative retinal disease

31 March 2020

1 reference

Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy

31 March 2020

1 reference

Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group

31 March 2020

1 reference

12 December 2020

Nephropathy in diabetes

1 reference

12 December 2020

Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy

1 reference

12 December 2020

Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy

1 reference

12 December 2020

Retinopathy in animal models of diabetes

1 reference

12 December 2020

Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study

1 reference

12 December 2020

Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Early Treatment Diabetic Retinopathy Study Research Group

1 reference

12 December 2020

MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial

1 reference

12 December 2020

Effects of aspirin treatment on diabetic retinopathy. ETDRS report number 8. Early Treatment Diabetic Retinopathy Study Research Group

1 reference

12 December 2020

Long-term effect of diabetes and its treatment on cognitive function.

1 reference

12 December 2020

Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (author's transl)

1 reference

12 December 2020

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

1 reference

12 December 2020

UK Prospective Diabetes Study (UKPDS). X. Urinary albumin excretion over 3 years in diet-treated type 2, (non-insulin-dependent) diabetic patients, and association with hypertension, hyperglycaemia and hypertriglyceridaemia

1 reference

12 December 2020

Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor

1 reference

12 December 2020

Vascular and neural changes in the rat optic nerve following induction of diabetes with streptozotocin

1 reference

12 December 2020

Patterns of ischemia in diabetic retinopathy

1 reference

12 December 2020

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

1 reference

12 December 2020

Nonhuman primate models of atherosclerosis: potential for the study of diabetes mellitus and hyperinsulinemia

1 reference

12 December 2020

A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Sorbinil Retinopathy Trial Research Group

1 reference

12 December 2020

Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2476

1 reference

Dimensions Publication ID

20 August 2017

1047465072

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