(Q37481238)

20 August 2017

1 reference

title

Chemokine receptor antagonists: Part 1. (English)

1 reference

20 August 2017

James E Pease

1

1 reference

PubMed ID

19441897

20 August 2017

Richard Horuk

series ordinal

2

1 reference

PubMed ID

19441897

20 August 2017

language of work or name

English

0 references

publication date

1 January 2009

1 reference

Expert Opinion on Therapeutic Patents

20 August 2017

1 reference

20 August 2017

19

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20 August 2017

1

1 reference

20 August 2017

39-58

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Chemokines: a new classification system and their role in immunity

20 August 2017

1 reference

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

21 January 2018

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Chemokines and leukocyte traffic

21 January 2018

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21 January 2018

Chemokines and disease

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

21 January 2018

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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

21 January 2018

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The clinical potential of chemokine receptor antagonists

21 January 2018

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Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents

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Recent developments in modulating chemokine networks

21 January 2018

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The attraction of chemokines as a target for specific anti-inflammatory therapy

21 January 2018

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Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

21 January 2018

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Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor

21 January 2018

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Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells.

21 January 2018

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Dominant myelopoietic effector functions mediated by chemokine receptor CCR1

21 January 2018

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Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1

21 January 2018

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Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury

21 January 2018

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Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model

21 January 2018

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CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.

21 January 2018

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Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection

21 January 2018

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Impact of engagement of FcepsilonRI and CC chemokine receptor 1 on mast cell activation and motility

21 January 2018

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Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1

21 January 2018

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A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection

21 January 2018

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A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation

21 January 2018

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Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model

21 January 2018

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CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases

21 January 2018

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Novel CCR1 antagonists with improved metabolic stability.

21 January 2018

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Potent small molecule CCR1 antagonists

21 January 2018

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The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template

21 January 2018

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The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice

21 January 2018

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Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor

21 January 2018

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Discovery of novel non-peptide CCR1 receptor antagonists

21 January 2018

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MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.

21 January 2018

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Design, synthesis, and discovery of a novel CCR1 antagonist

21 January 2018

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Discovery of a novel CCR3 selective antagonist

21 January 2018

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CCR1 chemokine receptor antagonist

21 January 2018

1 reference

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Identification of novel series of human CCR1 antagonists

21 January 2018

1 reference

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Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

21 January 2018

1 reference

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Chemokines and their receptors in allograft rejection

21 January 2018

1 reference

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Chemokines in rheumatic diseases

21 January 2018

1 reference

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The many roles of chemokines and chemokine receptors in inflammation

21 January 2018

1 reference

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Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts

21 January 2018

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Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis

21 January 2018

1 reference

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Differential effect of methotrexate on the increased CCR2 density on circulating CD4 T lymphocytes and monocytes in active chronic rheumatoid arthritis, with a down regulation only on monocytes in responders

21 January 2018

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MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.

21 January 2018

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Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

21 January 2018

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4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

21 January 2018

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Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.

21 January 2018

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Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.

21 January 2018

1 reference

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Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists

21 January 2018

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Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists

21 January 2018

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11th annual Inflammatory and Immune Diseases Drug Discovery and Development Summit 12-13 March 2007, San Francisco, USA.

21 January 2018

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Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives

21 January 2018

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Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives

21 January 2018

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Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.

21 January 2018

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Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

21 January 2018

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CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach

21 January 2018

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Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists

21 January 2018

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Structure and function of G protein-coupled receptors

21 January 2018

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Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.

21 January 2018

1 reference

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CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

21 January 2018

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Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists

21 January 2018

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2-Mercaptoimidazoles, a new class of potent CCR2 antagonists.

21 January 2018

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Substituted dipiperidine alcohols as potent CCR2 antagonists

21 January 2018

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Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists

21 January 2018

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N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor

21 January 2018

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Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

21 January 2018

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Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells

21 January 2018

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High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

21 January 2018

1 reference

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Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines

21 January 2018

1 reference

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A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation

21 January 2018

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A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

21 January 2018

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Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.

21 January 2018

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Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.

21 January 2018

1 reference

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Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists.

21 January 2018

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Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration

21 January 2018

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Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1.

21 January 2018

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Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.

21 January 2018

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Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists

21 January 2018

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Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.

21 January 2018

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CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.

21 January 2018

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Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists.

21 January 2018

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Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition.

21 January 2018

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In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031.

21 January 2018

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A novel, selective, and orally available antagonist for CC chemokine receptor 3.

21 January 2018

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Identification and characterization of novel antagonists of the CCR3 receptor.

21 January 2018

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The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists

21 January 2018

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The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists

21 January 2018

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Structure-activity relationships of 2-(benzothiazolylthio)acetamide class of CCR3 selective antagonist

21 January 2018

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Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction

21 January 2018

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CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge

21 January 2018

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Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions

21 January 2018

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CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo

21 January 2018

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CCR4 blockade does not inhibit allergic airways inflammation

21 January 2018

1 reference

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A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

21 January 2018

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Core exploration in optimization of chemokine receptor CCR4 antagonists

21 January 2018

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Optimization of 2-aminothiazole derivatives as CCR4 antagonists

21 January 2018

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Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines

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Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines

21 January 2018

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Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists.

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Blockade of chemokine signaling in patients with multiple sclerosis

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Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis

21 January 2018

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10.1517/13543770802641346

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19441897