(Q37485758)

English

Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Victoria Magrioti

object named as

Victoria Magrioti

3

0 references

Edward A. Dennis

object named as

Edward A Dennis

7

0 references

author name string

Georgia Antonopoulou

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Efrosini Barbayianni

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Naomi Cotton

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Daren Stephens

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Violetta Constantinou-Kokotou

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

George Kokotos

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

0 references

publication date

1 November 2008

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Bioorganic & Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

16

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

10257-10269

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Distinctiveness of secretory phospholipase A2 group IIA and V suggesting unique roles in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

The phospholipase A2 superfamily and its group numbering system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Group V sPLA2: classical and novel functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Inhibitors of secretory phospholipase A2 group IIA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Room-temperature Negishi cross-coupling of unactivated alkyl bromides with alkyl organozinc reagents utilizing a Pd/N-heterocyclic carbene catalyst

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Phospholipase A2 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Phospholipase A(2) regulation of arachidonic acid mobilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Synthetic routes and lipase-inhibiting activity of long-chain alpha-keto amides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Bis-2-oxo amide triacylglycerol analogues: a novel class of potent human gastric lipase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Synthesis of 2-Oxo amide triacylglycerol analogues and study of their inhibition effect on pancreatic and gastric lipases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Calcium-independent phospholipase A(2): structure and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Synthesis and study of a lipophilic alpha-keto amide inhibitor of pancreatic lipase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Expression and characterization of human group V phospholipase A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

23 August 2017

Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

6 September 2017

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

14 September 2017

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

14 September 2017

Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

14 September 2017

Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

26 June 2018

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

26 June 2018

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

2 September 2018

Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

2 September 2018

A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

2 September 2018

Synthesis and activity of 2-oxoamides containing long chain beta-amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

2 September 2018

Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

2 September 2018

Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

2 September 2018

Synthesis of lipophilic 2-oxoamides based on γ-aminobutyric and δ-aminovaleric analogues and their activity against phospholipase A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2796434

3 December 2018

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18993078

12 December 2020

based on heuristic

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Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18993078

12 December 2020

based on heuristic

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Synthesis of lipidic amino acid and dipeptide inhibitors of human platelet phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18993078

12 December 2020

based on heuristic

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Zwitterionic Sulfobetaine Inhibitors of Squalene Synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18993078

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Role of cytosolic phospholipase A2 in allergic response and parturition

1 reference

https://pubmed.ncbi.nlm.nih.gov/18993078

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Selective One-Pot Conversion of Carboxylic Acids into Alcohols

1 reference

https://pubmed.ncbi.nlm.nih.gov/18993078

12 December 2020

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Identifiers

10.1016/J.BMC.2008.10.046

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

ResearchGate publication ID

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