(Q37486720)

20 August 2017

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title

Epilepsy pharmacogenetics (English)

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20 August 2017

Dalia Kasperaviciūte

1

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20 August 2017

Sanjay M Sisodiya

series ordinal

2

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20 August 2017

publication date

1 May 2009

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20 August 2017

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20 August 2017

volume

10

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20 August 2017

issue

5

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20 August 2017

page(s)

817-836

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Management of epilepsy with diphenylhydantoin sodium. Dosage regulation for problem patients

20 August 2017

cites work

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The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics

21 January 2018

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The clinical impact of pharmacogenetics on the treatment of epilepsy

21 January 2018

1 reference

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

21 January 2018

1 reference

Case-control studies in the genomic era: a clinician's guide

21 January 2018

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The positives, protocols, and perils of genome-wide association

21 January 2018

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Neurodevelopmental delay in children exposed to antiepileptic drugs in utero: a critical review directed at structural study-bias

21 January 2018

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The longer term outcome of children born to mothers with epilepsy

21 January 2018

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Normal intelligence in children with prenatal exposure to carbamazepine

21 January 2018

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A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.

21 January 2018

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Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature

21 January 2018

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Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility

21 January 2018

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Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality

21 January 2018

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A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

21 January 2018

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Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero

21 January 2018

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Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR.

21 January 2018

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Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency

21 January 2018

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Increased susceptibility to phenytoin teratogenicity: excessive generation of reactive oxygen species or impaired antioxidant defense?

21 January 2018

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Prenatal prediction of risk of the fetal hydantoin syndrome

21 January 2018

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Expression and function of ABCB1 and ABCG2 in human placental tissue

21 January 2018

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Functional role of P-glycoprotein in the human blood-placental barrier

21 January 2018

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Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1).

21 January 2018

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Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

21 January 2018

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Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta

21 January 2018

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Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

21 January 2018

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Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

21 January 2018

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Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.

21 January 2018

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Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

21 January 2018

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Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.

21 January 2018

1 reference

Australian pregnancy registry of women taking antiepileptic drugs

21 January 2018

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The International Lamotrigine pregnancy registry update for the epilepsy foundation

21 January 2018

1 reference

Valproic acid teratogenicity: a toxicogenomics approach

21 January 2018

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Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives

21 January 2018

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Carbamazepine is an inhibitor of histone deacetylases

21 January 2018

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The activity of antiepileptic drugs as histone deacetylase inhibitors

21 January 2018

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Severe adverse cutaneous reactions to drugs

21 January 2018

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Comparison and predictors of rash associated with 15 antiepileptic drugs

21 January 2018

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Medical genetics: a marker for Stevens-Johnson syndrome

21 January 2018

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Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.

21 January 2018

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Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese

21 January 2018

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HLA-B locus in Caucasian patients with carbamazepine hypersensitivity

21 January 2018

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A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs

21 January 2018

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Effectiveness of first antiepileptic drug.

21 January 2018

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Idiosyncratic adverse reactions to antiepileptic drugs

21 January 2018

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Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

21 January 2018

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Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for increased serum gamma-glutamyltransferase in valproic acid-treated patients

21 January 2018

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Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).

21 January 2018

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21 January 2018

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Vigabatrin retinopathy in an Irish cohort: lack of correlation with dose.

21 January 2018

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The legacy of vigabatrin in a regional epilepsy clinic

21 January 2018

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Vigabatrin associated visual field loss: a clinical audit to study prevalence, drug history and effects of drug withdrawal

21 January 2018

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Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer

21 January 2018

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Utility of medical and drug history in fracture risk prediction among men and women

21 January 2018

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Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group.

21 January 2018

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Phenobarbital-induced alterations in vitamin D metabolism

21 January 2018

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Anti-epileptic medication and bone health

21 January 2018

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Bone health in people with epilepsy: is it impaired and what are the risk factors?

21 January 2018

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Antiepileptic drug use and rates of hip bone loss in older men: a prospective study

21 January 2018

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Multiple genetic loci for bone mineral density and fractures

21 January 2018

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New sequence variants associated with bone mineral density

21 January 2018

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Practice patterns of neurologists regarding bone and mineral effects of antiepileptic drug therapy

21 January 2018

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Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures

21 January 2018

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Valproic acid-associated weight gain in older children and teens with epilepsy

21 January 2018

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Weight change in monozygotic twins treated with valproate

21 January 2018

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Risk of excessive weight gain in epileptic children treated with valproate

21 January 2018

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Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions.

21 January 2018

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Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine

21 January 2018

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Weight variations in the prophylactic therapy of primary headaches: 6-month follow-up

21 January 2018

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A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis

21 January 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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Common variants near MC4R are associated with fat mass, weight and risk of obesity

21 January 2018

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

21 January 2018

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A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants

21 January 2018

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The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants

21 January 2018

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Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocysteinemia

21 January 2018

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Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy

21 January 2018

1 reference

Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy.

21 January 2018

1 reference

A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials.

21 January 2018

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Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: report of 33 mild to severe cases

21 January 2018

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Psychiatric adverse events during levetiracetam therapy

21 January 2018

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Revisiting the concept of identifiable neurons

21 January 2018

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Positive and negative psychotropic effects of levetiracetam

21 January 2018

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Complaints associated with the use of antiepileptic drugs: results from a community-based study

21 January 2018

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A cross-sectional study of subjective complaints in patients with epilepsy who seem to be well-controlled with anti-epileptic drugs.

21 January 2018

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Reversible language regression as an adverse effect of topiramate treatment in children

21 January 2018

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Significant improvement in frontal lobe associated neuropsychological functions after withdrawal of topiramate in epilepsy patients

21 January 2018

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The effects of adjunctive topiramate on cognitive function in patients with epilepsy

21 January 2018

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Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults.

21 January 2018

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Differential cognitive and behavioral effects of topiramate and valproate

21 January 2018

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Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up.

21 January 2018

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Neuropsychological and behavioral effects of antiepilepsy drugs

21 January 2018

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Multidrug resistance in epilepsy: a pharmacogenomic update

21 January 2018

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The temporal aspects of prognosis in epilepsy

21 January 2018

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Diagnosing refractory epilepsy: response to sequential treatment schedules

21 January 2018

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MDR1 gene expression in brain of patients with medically intractable epilepsy

21 January 2018

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Over-expression of P-glycoprotein in malformations of cortical development.

21 January 2018

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

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Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

21 January 2018

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Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

21 January 2018

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Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats

21 January 2018

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Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements

21 January 2018

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Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats

21 January 2018

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Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats.

21 January 2018

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Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.

21 January 2018

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

21 January 2018

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Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy

21 January 2018

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ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients.

21 January 2018

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Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey

21 January 2018

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Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study

21 January 2018

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Several major antiepileptic drugs are substrates for human P-glycoprotein

21 January 2018

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Interaction of antiepileptic drugs with human P-glycoprotein in vitro

21 January 2018

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

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Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs

21 January 2018

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Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis

21 January 2018

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Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.

21 January 2018

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The association between polymorphisms in RLIP76 and drug response in epilepsy

21 January 2018

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ABCC2 haplotype is not associated with drug-resistant epilepsy.

21 January 2018

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Likelihood of seizure remission in an adult population with refractory epilepsy

21 January 2018

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No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.

21 January 2018

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The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement

21 January 2018

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Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms

21 January 2018

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Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

21 January 2018

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A functional polymorphism in the SCN1A gene is not associated with carbamazepine dosages in Austrian patients with epilepsy

21 January 2018

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Association between SCN1A polymorphism and carbamazepine-resistant epilepsy

21 January 2018

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Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A.

21 January 2018

1 reference

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

21 January 2018

1 reference

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

21 January 2018

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Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility

21 January 2018

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Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

21 January 2018

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21 January 2018

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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

21 January 2018

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Identification of the gene for vitamin K epoxide reductase

21 January 2018

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Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study.

21 January 2018

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Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin

21 January 2018

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Genetic variation in an individual human exome

21 January 2018

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Genome-wide association studies for common diseases and complex traits

21 January 2018

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The complete genome of an individual by massively parallel DNA sequencing

21 January 2018

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Copy-number variations associated with neuropsychiatric conditions

21 January 2018

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Systematic assessment of copy number variant detection via genome-wide SNP genotyping

21 January 2018

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A robust statistical method for case-control association testing with copy number variation

21 January 2018

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Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers

21 January 2018

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Mapping determinants of human gene expression by regional and genome-wide association

21 January 2018

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Tissue-specific genetic control of splicing: implications for the study of complex traits

21 January 2018

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Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene

21 January 2018

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Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response.

21 January 2018

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Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses.

21 January 2018

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Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese

21 January 2018

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Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

21 January 2018

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Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics.

21 January 2018

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Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study

21 January 2018

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No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population

21 January 2018

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Hypovitaminosis D in Medical Inpatients

21 January 2018

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Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

21 January 2018

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A survey of genetic human cortical gene expression

21 January 2018

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Placental transfer of quetiapine in relation to P-glycoprotein activity

21 January 2018

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A pharmacogenetic exploration of vigabatrin-induced visual field constriction

21 January 2018

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Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

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The controversial association of ABCB1 polymorphisms in refractory epilepsy: An analysis of multiple SNPs in an Irish population

21 January 2018

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A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose

21 January 2018

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Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo

21 January 2018

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27 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1096/FJ.04-3425FJE

Identifiers

DOI

10.2217/PGS.09.34

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20 August 2017

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