(Q37488230)

20 August 2017

1 reference

title

ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders (English)

1 reference

20 August 2017

Jemima Barrowman

1

1 reference

PubMed ID

19453269

20 August 2017

Susan Michaelis

series ordinal

2

1 reference

20 August 2017

1 August 2009

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20 August 2017

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20 August 2017

390

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20 August 2017

8

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20 August 2017

761-773

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Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

20 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Genetic disorders of adipose tissue development, differentiation, and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Lipid posttranslational modifications. Farnesyl transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The prelamin A pre-peptide induces cardiac and skeletal myoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Nuclear lamins: laminopathies and their role in premature ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Human laminopathies: nuclei gone genetically awry

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Mechanisms of cardiovascular disease in accelerated aging syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

HIV protease inhibitors and nuclear lamin processing: getting the right bells and whistles

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Therapeutic intervention based on protein prenylation and associated modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The nuclear lamina comes of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Thematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

HIV-protease inhibitors block the enzymatic activity of purified Ste24p.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

New approaches to progeria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Biochemical studies of Zmpste24-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Genomic instability in laminopathy-based premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Small-molecule inhibitors of the Rce1p CaaX protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Nuclear lamins, diseases and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Protein farnesyltransferase inhibitors and progeria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Accelerated ageing: from mechanism to therapy through animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The laminopathies: a clinical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

An ABC transporter controls export of a Drosophila germ cell attractant

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The cell nucleus and aging: tantalizing clues and hopeful promises

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Lamin A-dependent nuclear defects in human aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Yeast genes controlling responses to topogenic signals in a model transmembrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

"Laminopathies": a wide spectrum of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Prelamin A farnesylation and progeroid syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2009.080

21 January 2018

Identifiers

DOI

10.1515/BC.2009.080

1 reference

20 August 2017

1 reference

PubMed ID

19453269