(Q34457223)

English

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

Europe PubMed Central

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

based on heuristic

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author name string

Stephen G Young

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Loren G Fong

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Susan Michaelis

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

publication date

5 October 2005

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Journal of Lipid Research

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

46

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2531-2558

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Rab GTPases, intracellular traffic and disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Modification of eukaryotic signaling proteins by C-terminal methylation reactions

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Life at the edge: the nuclear envelope and human disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

A-type lamins: guardians of the soma?

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Protein prenyltransferases

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Structure of tremerogen A-10, a peptidal hormone inducing conjugation tube formation in Tremella mesenterica.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

STE6, the yeast a-factor transporter

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Biochemical studies of Zmpste24-deficient mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Cloning and characterization of a mammalian prenyl protein-specific protease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Inhibitors of Ras farnesyltransferases

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The nuclear envelope, muscular dystrophy and gene expression

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Edible vaccines: not quite ready for prime time

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Head and/or CaaX domain deletions of lamin proteins disrupt preformed lamin A and C but not lamin B structure in mammalian cells

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Isoprenylation is required for the processing of the lamin A precursor

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Familial partial lipodystrophy: a monogenic form of the insulin resistance syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Molecular basis of partial lipodystrophy and prospects for therapy

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Lipodystrophies

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Mild brachydactyly type A1 maps to chromosome 2q35-q36 and is caused by a novel IHH mutation in a three generation family

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

LMNA mutations in atypical Werner's syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Structure of the globular tail of nuclear lamin

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Lamin B1 is required for mouse development and nuclear integrity

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Characterization of adiposity and metabolism in Lmna-deficient mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Starvation in man

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

A progeroid syndrome in mice is caused by defects in A-type lamins

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090).

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Lamin a truncation in Hutchinson-Gilford progeria.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Lamin A expression levels are unperturbed at the normal and mutant alleles but display partial splice site selection in Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Molecular cytogenetic insights into the ageing syndrome Hutchinson-Gilford Progeria (HGPS).

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Altered pre-lamin A processing is a common mechanism leading to lipodystrophy.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Genomic instability in laminopathy-based premature aging

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Mad Bet for Rab

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R500011-JLR200

21 January 2018

Identifiers

10.1194/JLR.R500011-JLR200

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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