(Q33934228)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Ann M Winter-Vann

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Rudi A Baron

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Waihay Wong

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

June dela Cruz

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

John D York

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

David M Gooden

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Martin O Bergo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Eric J Toone

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Patrick J Casey

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

English

0 references

publication date

1 March 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

4336-4341

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

Farnesyltransferase inhibitors as anticancer agents: critical crossroads.

9 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Fighting cancer by disrupting C-terminal methylation of signaling proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Carboxyl methylation of Ras regulates membrane targeting and effector engagement

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Current status of clinical trials of farnesyltransferase inhibitors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

cDNA array analyses of K-ras-induced gene transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Cell signaling by receptor tyrosine kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Understanding Ras: 'it ain't over 'til it's over'.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Functional roles for fatty acylated amino-terminal domains in subcellular localization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Cloning and characterization of a mammalian prenyl protein-specific protease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Protein prenylation: molecular mechanisms and functional consequences

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

S-Adenosylmethionine and methylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Farnesyl analogues inhibit vasoconstriction in animal and human arteries

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Protein prenyltransferases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Biological assays for Ras transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Farnesylcysteine analogues inhibit chemotactic peptide receptor-mediated G-protein activation in human HL-60 granulocyte membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

All ras proteins are polyisoprenylated but only some are palmitoylated

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

ras oncogenes in human cancer: a review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=555472

RAS oncogenes: the first 30 years.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0408107102

The discovery of receptor tyrosine kinases: targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0408107102

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0408107102

Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0408107102

Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransferase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15784746

12 December 2020

inferred from PubMed ID database lookup

Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15784746

12 December 2020

inferred from PubMed ID database lookup

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15784746

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0408107102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784746%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference