(Q37488585)

English

Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin

scientific article published on 02 December 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

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Saumendra N Sarkar

object named as

Saumendra N Sarkar

14

0 references

object named as

Xinhua Ji

7

0 references

10

object named as

Peter Wipf

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Eun-Ryeong Hahm

3

object named as

Eun-Ryeong Hahm

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Shivendra V Singh

15

object named as

Shivendra V Singh

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Marie L Antony

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Joomin Lee

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Su-Hyeong Kim

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Adam I Marcus

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Vandana Kumari

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Zhen Yang

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Courtney L Vowell

9

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Guy T Uechi

11

1 reference

Europe PubMed Central

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20 August 2017

Nathan A Yates

12

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Europe PubMed Central

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20 August 2017

Guillermo Romero

13

1 reference

Europe PubMed Central

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20 August 2017

language of work or name

0 references

publication date

2 December 2013

1 reference

Europe PubMed Central

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20 August 2017

number of pages

14

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

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20 August 2017

289

1 reference

Europe PubMed Central

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20 August 2017

3

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Europe PubMed Central

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20 August 2017

1852-1865

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

1 reference

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23 August 2017

Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.

1 reference

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Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach

1 reference

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23 August 2017

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

1 reference

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The resurgence of covalent drugs

1 reference

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23 August 2017

Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Microtubules and resistance to tubulin-binding agents

1 reference

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

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Protein structure prediction on the Web: a case study using the Phyre server

1 reference

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23 August 2017

Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

The tubulin code

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

In-gel digestion for mass spectrometric characterization of proteins and proteomes

1 reference

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23 August 2017

Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Withaferin A is a potent inhibitor of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Microtubules as a target for anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

The anaphase-promoting complex: proteolysis in mitosis and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

23 August 2017

Molecularly targeted therapies for metastatic triple-negative breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

6 September 2017

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

6 September 2017

An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

14 September 2017

Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894360

28 September 2017

Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters.

1 reference

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2 September 2018

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Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum

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Rates and Equilibria of the Michael-Type Addition of Benzenethiol to 2-Cyclopenten-1-ones

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Transition States and Energetics of Nucleophilic Additions of Thiols to Substituted α,β-Unsaturated Ketones: Substituent Effects Involve Enone Stabilization, Product Branching, and Solvation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24297176

12 December 2020

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Effect of withaferin a on Ehrlich ascites tumor cells. II. Target tumor cell destructionin vivoby immune activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24297176

12 December 2020

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Influence of Base and Structure in the Reversible Covalent Conjugate Addition of Thiol to Polycyclic Enone Scaffolds

1 reference

https://pubmed.ncbi.nlm.nih.gov/24297176

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24297176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera

1 reference

https://pubmed.ncbi.nlm.nih.gov/24297176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.496844

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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