(Q37506110)

20 August 2017

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title

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins (English)

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20 August 2017

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3

Nenad Ban

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20 August 2017

4

Bernd Bukau

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20 August 2017

2

Daniel Boehringer

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20 August 2017

Günter Kramer

1

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20 August 2017

publication date

1 June 2009

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Nature Structural & Molecular Biology

20 August 2017

published in

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20 August 2017

volume

16

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20 August 2017

issue

6

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20 August 2017

page(s)

589-597

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Protein N-terminal methionine excision.

20 August 2017

cites work

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Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria

21 January 2018

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Genomic expression programs in the response of yeast cells to environmental changes

21 January 2018

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ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.

21 January 2018

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Correlating ribosome function with high-resolution structures

21 January 2018

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The native 3D organization of bacterial polysomes

31 March 2020

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

31 March 2020

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High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

31 March 2020

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The structural basis of ribosome activity in peptide bond synthesis

31 March 2020

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The Geometry of the Ribosomal Polypeptide Exit Tunnel

31 March 2020

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Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation.

31 March 2020

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Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shielding

31 March 2020

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Tertiary interactions within the ribosomal exit tunnel

31 March 2020

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Mapping the electrostatic potential within the ribosomal exit tunnel

31 March 2020

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Folding zones inside the ribosomal exit tunnel

31 March 2020

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Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima

31 March 2020

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Protein folding within the cell is influenced by controlled rates of polypeptide elongation

31 March 2020

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Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation

31 March 2020

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Transient ribosomal attenuation coordinates protein synthesis and co-translational folding.

31 March 2020

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

31 March 2020

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Protein secondary structural types are differentially coded on messenger RNA.

31 March 2020

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31 March 2020

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Folding at the rhythm of the rare codon beat

31 March 2020

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Electrostatics in the ribosomal tunnel modulate chain elongation rates

31 March 2020

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Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeast

31 March 2020

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Nascent peptide-dependent translation arrest leads to Not4p-mediated protein degradation by the proteasome

31 March 2020

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Instruction of translating ribosome by nascent peptide

31 March 2020

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Secretion monitor, SecM, undergoes self-translation arrest in the cytosol

31 March 2020

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Translocon “Pulling” of Nascent SecM Controls the Duration of Its Translational Pause and Secretion-Responsive secA Regulation

31 March 2020

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Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.

31 March 2020

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The ribosomal exit tunnel functions as a discriminating gate

31 March 2020

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Genetically encoded but nonpolypeptide prolyl-tRNA functions in the A site for SecM-mediated ribosomal stall.

31 March 2020

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A nascent polypeptide domain that can regulate translation elongation

31 March 2020

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Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

31 March 2020

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A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

31 March 2020

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Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

31 March 2020

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Cotranslational folding promotes beta-helix formation and avoids aggregation in vivo

31 March 2020

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Extent of N-terminal modifications in cytosolic proteins from eukaryotes.

31 March 2020

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Tools for analyzing and predicting N-terminal protein modifications

31 March 2020

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Cleavage of the N-terminal formymlethionine residue from a bacteriophage coat protein in vitro

31 March 2020

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Association of protein biogenesis factors at the yeast ribosomal tunnel exit is affected by the translational status and nascent polypeptide sequence

31 March 2020

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Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo.

31 March 2020

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Evidence that two zinc fingers in the methionine aminopeptidase from Saccharomyces cerevisiae are important for normal growth

31 March 2020

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Amidohydrolase activity of Escherichia coli extracts with formylated amino acids and dipeptides as substrates.

31 March 2020

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On the release of the formyl group from nascent protein

31 March 2020

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A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing

31 March 2020

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Composition and function of the eukaryotic N-terminal acetyltransferase subunits

31 March 2020

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Rat liver polysome N alpha-acetyltransferase: isolation and characterization

31 March 2020

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Acetylation of nascent polypeptide chains on rat liver polyribosomes in vivo and in vitro

31 March 2020

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Ovalbumin: a secreted protein without a transient hydrophobic leader sequence

31 March 2020

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Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes

31 March 2020

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The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides

31 March 2020

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Converging concepts of protein folding in vitro and in vivo

31 March 2020

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L23 protein functions as a chaperone docking site on the ribosome

31 March 2020

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Interaction of trigger factor with the ribosome

31 March 2020

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Real-time observation of trigger factor function on translating ribosomes.

31 March 2020

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Dynamics of trigger factor interaction with translating ribosomes

31 March 2020

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Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences.

31 March 2020

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Dynamic association of trigger factor with protein substrates

31 March 2020

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Binding specificity of Escherichia coli trigger factor

31 March 2020

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Trigger Factor and DnaK possess overlapping substrate pools and binding specificities

31 March 2020

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Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed

31 March 2020

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Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.

31 March 2020

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Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

31 March 2020

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The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction.

31 March 2020

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Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action

31 March 2020

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Trigger factor forms a protective shield for nascent polypeptides at the ribosome.

31 March 2020

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Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains

31 March 2020

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Identification of nascent chain interaction sites on trigger factor

31 March 2020

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Cooperation of enzymatic and chaperone functions of trigger factor in the catalysis of protein folding

31 March 2020

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Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains

31 March 2020

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The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity.

31 March 2020

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A protein complex required for signal-sequence-specific sorting and translocation

31 March 2020

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The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex

31 March 2020

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A functional chaperone triad on the yeast ribosome

31 March 2020

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Molecular guardians for newborn proteins: ribosome-associated chaperones and their role in protein folding

31 March 2020

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RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin.

31 March 2020

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The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain

31 March 2020

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Zuotin, a ribosome-associated DnaJ molecular chaperone

31 March 2020

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Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells

31 March 2020

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The translation machinery and 70 kd heat shock protein cooperate in protein synthesis

31 March 2020

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Ribosome-associated complex binds to ribosomes in close proximity of Rpl31 at the exit of the polypeptide tunnel in yeast

31 March 2020

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The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.

31 March 2020

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Functional characterization of the atypical Hsp70 subunit of yeast ribosome-associated complex

31 March 2020

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Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous

31 March 2020

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The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex

31 March 2020

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Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p

31 March 2020

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Hsp110 cooperates with different cytosolic HSP70 systems in a pathway for de novo folding

31 March 2020

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Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor

31 March 2020

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Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae

31 March 2020

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Insights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1

31 March 2020

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Nascent-polypeptide-associated complex

31 March 2020

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The crystal structure of archaeal nascent polypeptide-associated complex (NAC) reveals a unique fold and the presence of a ubiquitin-associated domain.

31 March 2020

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The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions

31 March 2020

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A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains

31 March 2020

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Characterisation of the nascent polypeptide-associated complex in fission yeast

31 March 2020

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Initial characterization of the nascent polypeptide-associated complex in yeast

31 March 2020

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Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.

31 March 2020

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An insertional mutation in theBTF3 transcription factor gene leads to an early postimplantation lethality in mice

31 March 2020

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Ribosome-tethered molecular chaperones: the first line of defense against protein misfolding?

31 March 2020

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Structures of the bacterial ribosome at 3.5 A resolution

31 March 2020

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Distinct modes of signal recognition particle interaction with the ribosome

31 March 2020

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Architecture of the protein-conducting channel associated with the translating 80S ribosome

31 March 2020

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Structure of the signal recognition particle interacting with the elongation-arrested ribosome.

31 March 2020

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Structure of the E. coli signal recognition particle bound to a translating ribosome.

31 March 2020

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Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1.

31 March 2020

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Structure of the E. coli protein-conducting channel bound to a translating ribosome

31 March 2020

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The signal recognition particle

31 March 2020

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Cellular mechanisms of membrane protein folding

31 March 2020

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Ligand crowding at a nascent signal sequence

31 March 2020

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Alternate recruitment of signal recognition particle and trigger factor to the signal sequence of a growing nascent polypeptide

31 March 2020

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Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle

31 March 2020

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Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

31 March 2020

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Simultaneous binding of trigger factor and signal recognition particle to the E. coli ribosome.

31 March 2020

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Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor

31 March 2020

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The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal

31 March 2020

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Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor

31 March 2020

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Trigger factor retards protein export in Escherichia coli.

31 March 2020

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Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli.

31 March 2020

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Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor

31 March 2020

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Following the signal sequence from ribosomal tunnel exit to signal recognition particle

31 March 2020

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Conformation of the signal recognition particle in ribosomal targeting complexes

31 March 2020

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Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum

31 March 2020

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The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex

31 March 2020

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A general mechanism for regulation of access to the translocon: competition for a membrane attachment site on ribosomes

31 March 2020

1 reference

Kinetics of maturation of the amino termini of the cell proteins of Escherichia coli

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19491936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acetylation of peptidyl-tRNA on rat liver polyribosomes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19491936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19491936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1614

1 reference

Dimensions Publication ID

20 August 2017

1049933447

0 references

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