(Q37510564)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

title

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Michael G. Roth

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Dirk Daelemans

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Pier Paolo Scaglioni

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

20

Ignacio I Wistuba

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

author name string

Jimi Kim

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Elizabeth McMillan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Hyun Seok Kim

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Niranjan Venkateswaran

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Gurbani Makkar

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Jaime Rodriguez-Canales

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Pamela Villalobos

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Saurabh Mendiratta

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Shuguang Wei

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Yosef Landesman

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

William Senapedis

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Erkan Baloglu

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Chi-Wan B Chow

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Robin E Frink

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Boning Gao

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

John D Minna

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Bruce A Posner

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Michael A White

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

language of work or name

English

0 references

publication date

28 September 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

volume

538

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

page(s)

114-117

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

issue

7623

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

24 March 2020

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5161658/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nature19771

0 references

cites work

First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Drugging the undruggable RAS: Mission possible?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

IKK is a therapeutic target in KRAS-Induced lung cancer with disrupted p53 activity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

KRAS and YAP1 converge to regulate EMT and tumor survival

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

siMacro: A Fast and Easy Data Processing Tool for Cell-Based Genomewide siRNA Screens

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Proliferative potential and phenotypic analysis of long-term cultivated human granulosa cells initiated by addition of follicular fluid

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

PIK3CA mutations and copy number gains in human lung cancers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Clustering by passing messages between data points

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Cytoscape: a software environment for integrated models of biomolecular interaction networks

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

NCI-Navy Medical Oncology Branch cell line data base

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161658

2 September 2018

Identifiers

DOI

10.1038/NATURE19771

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680702%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference