(Q37515414)

20 August 2017

1 reference

title

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls (English)

1 reference

20 August 2017

Matthias Brandsch

1

1 reference

PubMed ID

19519280

20 August 2017

language of work or name

English

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publication date

1 August 2009

1 reference

Expert Opinion on Drug Metabolism & Toxicology

20 August 2017

1 reference

20 August 2017

5

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20 August 2017

887-905

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20 August 2017

8

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Pharmaceutical and pharmacological importance of peptide transporters

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Peptide transporters: structure, function, regulation and application for drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Peptide and peptide analog transport systems at the blood-CSF barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Expression cloning of a mammalian proton-coupled oligopeptide transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

The renal type H+/peptide symporter PEPT2: structure-affinity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Evidence for the Absolute Conformational Specificity of the Intestinal H+/Peptide Symporter, PEPT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

4-aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Structural requirements for interaction with the oligopeptide transporter in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Transport of beta-lactam antibiotics in kidney brush border membrane. Determinants of their affinity for the oligopeptide/H+ symporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Stereoselective uptake of beta-lactam antibiotics by the intestinal peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

The intestinal H+/peptide symporter PEPT1: structure-affinity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Review. The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Lack of interaction between the peptidomimetic substrates captopril and cephradine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

High-affinity interaction of sartans with H+/peptide transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Synthesis, transport and pharmacokinetics of 5'-amino acid ester prodrugs of 1-beta-D-arabinofuranosylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Peptide derivation of poorly absorbable drug allows intestinal absorption via peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Synthesis and characterization of a new and radiolabeled high-affinity substrate for H+/peptide cotransporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Delineation of human peptide transporter 1 (hPepT1)-mediated uptake and transport of substrates with varying transporter affinities utilizing stably transfected hPepT1/Madin-Darby canine kidney clones and Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903042292

10.1517/17425250903042292

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19519280