(Q39994950)

16 September 2017

title

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity (English)

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16 September 2017

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3

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6

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8

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9

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16 September 2017

José Morais

2

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Bente Steffansen

object named as

Bente Steffansen

series ordinal

7

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Christophe Pannecouque

object named as

Christophe Pannecouque

series ordinal

5

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Erik De Clercq

object named as

Erik de Clercq

series ordinal

4

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publication date

1 June 2008

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16 September 2017

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16 September 2017

volume

3

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16 September 2017

issue

6

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16 September 2017

page(s)

970-978

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The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

16 September 2017

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Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

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Site-specific, sustained release of drugs to the brain.

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Ester prodrugs of zidovudine

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Synthesis and biological evaluation of prodrugs of zidovudine

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Synthesis and evaluation of novel ether lipid nucleoside conjugates for anti-HIV-1 activity

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Lipid conjugates of antiretroviral agents. I. Azidothymidine-monophosphate-diglyceride: anti-HIV activity, physical properties, and interaction with plasma proteins

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AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system

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Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine

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A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

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Direct transport of 2',3'-didehydro-3'-deoxythymidine (D4T) and its ester derivatives to the cerebrospinal fluid via the nasal mucous membrane in rats

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Synthesis, in vitro kinetics, and in vivo studies on protein conjugates of AZT: evaluation as a transport system to increase brain delivery

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5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

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7 January 2021

Synthesis and characterization of novel dipeptide ester prodrugs of acyclovir

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7 January 2021

In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model

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Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations

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Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification

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Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats

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Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol

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7 January 2021

Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir

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7 January 2021

Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter

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7 January 2021

Conjugation of dipeptide to fluorescent dyes enhances its affinity for a dipeptide transporter (PEPT1) in human intestinal Caco-2 cells

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7 January 2021

hPEPT1 affinity and translocation of selected Gln-Sar and Glu-Sar dipeptide derivatives.

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7 January 2021

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200800012

1 reference

16 September 2017

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