(Q37520732)

20 August 2017

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title

Hypocretin mechanisms in nicotine addiction: evidence and speculation (English)

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20 August 2017

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William A Corrigall

1

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20 August 2017

publication date

16 June 2009

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20 August 2017

number of pages

15

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inferred from page(s)

published in

Psychopharmacology

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20 August 2017

volume

206

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20 August 2017

issue

1

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20 August 2017

page(s)

23-37

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Nicotine and attention: event-related potential investigations in nonsmokers

20 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00213-009-1588-2

Nicotine-induced limbic cortical activation in the human brain: a functional MRI study

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00213-009-1588-2

Differences between smokers and nonsmokers in regional gray matter volumes and densities

21 January 2018

1 reference

12 December 2020

1 reference

12 December 2020

Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence.

1 reference

12 December 2020

A role for brain stress systems in addiction

1 reference

12 December 2020

Colocalization of gamma-aminobutyric acid and acetylcholine in neurons in the laterodorsal and pedunculopontine tegmental nuclei in the cat: a light and electron microscopic study

1 reference

12 December 2020

A functional magnetic resonance imaging (FMRI) study of cue-induced smoking craving in virtual environments

1 reference

12 December 2020

Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.

1 reference

12 December 2020

Regional brain activity correlates of nicotine dependence

1 reference

12 December 2020

Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats

1 reference

12 December 2020

Long-term potentiation of excitatory inputs to brain reward areas by nicotine.

1 reference

12 December 2020

Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF n

1 reference

12 December 2020

Review. Context-induced relapse to drug seeking: a review

1 reference

12 December 2020

Excitatory action of hypocretin/orexin on neurons of the central medial amygdala

1 reference

12 December 2020

Orexin receptor antagonists: medicinal chemistry and therapeutic potential

1 reference

12 December 2020

Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats.

1 reference

12 December 2020

A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues

1 reference

12 December 2020

Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area

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12 December 2020

Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat.

1 reference

12 December 2020

Electrophysiological effects of orexins/hypocretins on pedunculopontine tegmental neurons in rats: an in vitro study

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12 December 2020

Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental area

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12 December 2020

Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.

1 reference

12 December 2020

Orbitofrontal cortex, decision-making and drug addiction

1 reference

12 December 2020

Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal

1 reference

12 December 2020

Role of alpha7 nicotinic receptors in nicotine dependence and implications for psychiatric illness

1 reference

12 December 2020

Hypocretin/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area

1 reference

12 December 2020

Role of lateral hypothalamic orexin neurons in reward processing and addiction

1 reference

12 December 2020

The neurocircuitry of addiction: an overview

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12 December 2020

Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats

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12 December 2020

Drug addiction and the memory systems of the brain.

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12 December 2020

Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area

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12 December 2020

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei

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12 December 2020

Glutamate-Like Immunoreactivity is Present within Cholinergic Neurons of the Laterodorsal Tegmental and Pedunculopontine Nuclei

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12 December 2020

Brain stem circuits mediating prepulse inhibition of the startle reflex

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12 December 2020

Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission

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12 December 2020

Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas

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12 December 2020

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.

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12 December 2020

Imaging brain activation in nicotine-sensitized rats

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12 December 2020

Schizophrenia, hypocretin (orexin), and the thalamocortical activating system

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12 December 2020

Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area.

1 reference

12 December 2020

Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure

1 reference

12 December 2020

Pedunculopontine nucleus in the squirrel monkey: distribution of cholinergic and monoaminergic neurons in the mesopontine tegmentum with evidence for the presence of glutamate in cholinergic neurons

1 reference

12 December 2020

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

1 reference

12 December 2020

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

1 reference

12 December 2020

Narcolepsy: pathophysiology and pharmacology

1 reference

12 December 2020

Hypocretins/orexins as integrators of physiological information: lessons from mutant animals

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12 December 2020

Instructed smoking expectancy modulates cue-elicited neural activity: a preliminary study

1 reference

12 December 2020

Hypocretin (orexin): role in normal behavior and neuropathology

1 reference

12 December 2020

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats

1 reference

12 December 2020

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

1 reference

12 December 2020

Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

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12 December 2020

Role of dopamine in the behavioural actions of nicotine related to addiction

1 reference

12 December 2020

Selective c-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome

1 reference

12 December 2020

Nicotine withdrawal syndrome: behavioural distress and selective up-regulation of the cyclic AMP pathway in the amygdala

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12 December 2020

Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

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12 December 2020

Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice

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12 December 2020

Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins.

1 reference

12 December 2020

Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.

1 reference

12 December 2020

High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging

1 reference

12 December 2020

Distribution of orexin neurons in the adult rat brain

1 reference

12 December 2020

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

1 reference

12 December 2020

The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study

1 reference

12 December 2020

Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy

1 reference

12 December 2020

Varenicline improves mood and cognition during smoking abstinence

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12 December 2020

Effects of nicotinic stimulation on cognitive performance

1 reference

12 December 2020

The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons

1 reference

12 December 2020

Neurons containing hypocretin (orexin) project to multiple neuronal systems

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12 December 2020

Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal

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12 December 2020

Translational research in medication development for nicotine dependence

1 reference

12 December 2020

Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6).

1 reference

12 December 2020

Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat.

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12 December 2020

Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area

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12 December 2020

In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice

1 reference

12 December 2020

Chronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the rat.

1 reference

12 December 2020

Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction

1 reference

12 December 2020

Presynaptic nicotinic ACh receptors

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12 December 2020

The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

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12 December 2020

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

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12 December 2020

Nicotine effects on regional cerebral blood flow in awake, resting tobacco smokers

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12 December 2020

The hypocretin/orexin receptor: therapeutic prospective in sleep disorders

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12 December 2020

Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging

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12 December 2020

A role for lateral hypothalamic orexin neurons in reward seeking

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12 December 2020

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

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12 December 2020

Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons

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12 December 2020

The neurobiology of addiction: a neuroadaptational view relevant for diagnosis

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12 December 2020

Muscarinic-2 and orexin-2 receptors on GABAergic and other neurons in the rat mesopontine tegmentum and their potential role in sleep-wake state control

1 reference

12 December 2020

Functional brain imaging of tobacco use and dependence

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12 December 2020

The hypocretins: setting the arousal threshold

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12 December 2020

The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected].

1 reference

12 December 2020

How best to consider the structure and function of the pedunculopontine tegmental nucleus: evidence from animal studies.

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12 December 2020

The role of the hypocretinergic system in the integration of networks that dictate the states of arousal.

1 reference

12 December 2020

Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats

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12 December 2020

Differential expression of orexin receptors 1 and 2 in the rat brain

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12 December 2020

Nicotine up-regulates expression of orexin and its receptors in rat brain

1 reference

12 December 2020

Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study

1 reference

12 December 2020

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

1 reference

12 December 2020

Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups

1 reference

12 December 2020

Cellular and synaptic mechanisms of nicotine addiction

1 reference

12 December 2020

Nicotinic modulation of neuronal networks: from receptors to cognition

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12 December 2020

Arousal and reward: a dichotomy in orexin function

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12 December 2020

Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration

1 reference

12 December 2020

Addiction and arousal: alternative roles of hypothalamic peptides.

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12 December 2020

Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons.

1 reference

12 December 2020

Regional cerebral blood flow effects of nicotine in overnight abstinent smokers

1 reference

12 December 2020

The effects of acute nicotine on the metabolism of dopamine and the expression of Fos protein in striatal and limbic brain areas of rats during chronic nicotine infusion and its withdrawal.

1 reference

12 December 2020

Cognitive mechanisms of nicotine on visual attention

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12 December 2020

Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons

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12 December 2020

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

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12 December 2020

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

1 reference

12 December 2020

Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

1 reference

12 December 2020

Exclusive postsynaptic action of hypocretin-orexin on sublayer 6b cortical neurons

1 reference

12 December 2020

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

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12 December 2020

Dopaminergic regulation of orexin neurons

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12 December 2020

Place preference conditioning with ventral tegmental injections of cytisine

1 reference

12 December 2020

Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus.

1 reference

12 December 2020

Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex

1 reference

12 December 2020

Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons

1 reference

12 December 2020

Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus

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12 December 2020

Neuropeptides as possible targets in sleep disorders: special emphasis on hypocretin-deficient narcolepsy

1 reference

12 December 2020

Identification of neurons containing orexin-B (hypocretin-2) immunoreactivity in limbic structures

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12 December 2020

Modulatory effects of hypocretin-1/orexin-A with glutamate and gamma-aminobutyric acid on freshly isolated pyramidal neurons from the rat prefrontal cortex.

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12 December 2020

Modulation of thalamic neuron excitability by orexins.

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12 December 2020

Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system.

1 reference

12 December 2020

Neural substrates of resisting craving during cigarette cue exposure.

1 reference

12 December 2020

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1 reference

12 December 2020

Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy

1 reference

12 December 2020

Postsynaptic excitation of prefrontal cortical pyramidal neurons by hypocretin-1/orexin A through the inhibition of potassium currents

1 reference

12 December 2020

PET studies of the influences of nicotine on neural systems in cigarette smokers

1 reference

12 December 2020

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

1 reference

12 December 2020

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

1 reference

12 December 2020

Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress

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12 December 2020

Nicotine-induced fos expression in the pedunculopontine mesencephalic tegmentum in the rat.

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12 December 2020

Behavioral correlates of activity in identified hypocretin/orexin neurons

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12 December 2020

The pedunculopontine nucleus--auditory input, arousal and pathophysiology

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12 December 2020

Expression of orexin receptors in the brain and peripheral tissues of the male sheep

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12 December 2020

The orbital prefrontal cortex and drug addiction in laboratory animals and humans

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12 December 2020

Common neural substrates for the addictive properties of nicotine and cocaine.

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12 December 2020

Stimulation of cortical acetylcholine release by orexin A

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12 December 2020

Integration of feeding and spontaneous physical activity: role for orexin

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12 December 2020

Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry.

1 reference

12 December 2020

Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum

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12 December 2020

Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels

1 reference

12 December 2020

Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

1 reference

12 December 2020

Activation of orexin/hypocretin projections to basal forebrain and paraventricular thalamus by acute nicotine

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12 December 2020

Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: an fMRI study.

1 reference

12 December 2020

Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers

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12 December 2020

Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine

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12 December 2020

Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: an fMRI study

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12 December 2020

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

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12 December 2020

Pharmacological manipulations of the pedunculopontine tegmental nucleus in the rat reduce self-administration of both nicotine and cocaine

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12 December 2020

Region-specific effects of nicotine on brain activity: a pharmacological MRI study in the drug-naïve rat.

1 reference

12 December 2020

The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction.

1 reference

12 December 2020

Sub-chronic nicotine-induced changes in regional cerebral blood volume and transversal relaxation time patterns in the rat: a magnetic resonance study

1 reference

12 December 2020

The orexin system regulates alcohol-seeking in rats

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12 December 2020

Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens

1 reference

12 December 2020

The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

1 reference

12 December 2020

Neural substrates of abstinence-induced cigarette cravings in chronic smokers

1 reference

12 December 2020

Activation of orexin neurons by acute nicotine.

1 reference

12 December 2020

Paraventricular thalamic nucleus: subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys

1 reference

12 December 2020

Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain

1 reference

12 December 2020

Promotion of sleep by targeting the orexin system in rats, dogs and humans

1 reference

12 December 2020

Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery

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12 December 2020

Structural plasticity associated with exposure to drugs of abuse

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12 December 2020

Insular hypocretin transmission regulates nicotine reward

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12 December 2020

Distribution of orexin receptor mRNA in the rat brain

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12 December 2020

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

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12 December 2020

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.

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12 December 2020

1 reference

12 December 2020

The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations

1 reference

12 December 2020

GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively in the rat.

1 reference

12 December 2020

Review. Neurobiology of nicotine dependence

1 reference

12 December 2020

Smoking impacts on prefrontal attentional network function in young adult brains

1 reference

12 December 2020

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

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12 December 2020

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

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12 December 2020

Genetic dissociation of two behaviors associated with nicotine addiction: beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome.

1 reference

12 December 2020

The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction?

1 reference

12 December 2020

Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

1 reference

12 December 2020

Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental area

1 reference

12 December 2020

The neural basis of drug craving: an incentive-sensitization theory of addiction

1 reference

12 December 2020

The paraventricular nucleus of the thalamus as an interface between the orexin and CART peptides and the shell of the nucleus accumbens.

1 reference

12 December 2020

Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues

1 reference

12 December 2020

Nicotine effects on brain function and functional connectivity in schizophrenia

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12 December 2020

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors

1 reference

12 December 2020

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

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12 December 2020

Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence

1 reference

12 December 2020

Neurocognitive and neuroimaging evidence of behavioural dysregulation in human drug addiction: implications for diagnosis, treatment and prevention

1 reference

12 December 2020

Effect of acupuncture on anxiety-like behavior during nicotine withdrawal and relevant mechanisms

1 reference

12 December 2020

Orexin-induced modulation of state-dependent intrinsic properties in thalamic paraventricular nucleus neurons attenuates action potential patterning and frequency

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12 December 2020

Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia.

1 reference

12 December 2020

Nicotine: from molecular mechanisms to behaviour

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12 December 2020

The neural basis of addiction: a pathology of motivation and choice

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12 December 2020

Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat.

1 reference

12 December 2020

10.1007/S00213-009-1588-2

Identifiers

DOI

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20 August 2017

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