(Q37525589)

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A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation

scientific article published on 28 January 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

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author name string

Peng Chen

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Li Zhang

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Tujun Weng

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Shichang Zhang

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Shijin Sun

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Mingtao Chang

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Yang Li

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Bo Zhang

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Lianyang Zhang

9

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

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publication date

28 January 2014

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Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

9

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Europe PubMed Central

PMC publication ID

20 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

e87311

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

copyright license

Creative Commons Attribution 4.0 International

28 January 2014

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April 2022 Public Data File from Crossref

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0 references

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia.

1 reference

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Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice

1 reference

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23 August 2017

Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis

1 reference

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23 August 2017

FGF signaling: its role in bone development and human skeleton diseases

1 reference

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1 reference

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Osteogenic differentiation of human marrow-derived mesenchymal stem cells

1 reference

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Fibroblast growth factor expression in the postnatal growth plate

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Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation

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23 August 2017

A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis.

1 reference

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23 August 2017

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

1 reference

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23 August 2017

FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

1 reference

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23 August 2017

Bone marrow stromal stem cells: nature, biology, and potential applications

1 reference

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23 August 2017

Fibroblast growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

23 August 2017

Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes

1 reference

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23 August 2017

A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia

1 reference

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23 August 2017

Bone development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

23 August 2017

Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts

1 reference

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23 August 2017

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

1 reference

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23 August 2017

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

23 August 2017

Analysis of phenotypic features and FGFR2 mutations in Apert syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

23 August 2017

Cbfa1 is a positive regulatory factor in chondrocyte maturation

1 reference

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6 September 2017

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

1 reference

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6 September 2017

Craniosynostosis update 1987.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

14 September 2017

Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling

1 reference

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14 September 2017

Fibroblast-growth-factor receptor mutations in human skeletal disorders

1 reference

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28 September 2017

Skeletal abnormalities in the Apert syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

28 September 2017

A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904987

25 June 2018

Role of N-cadherin and protein kinase C in osteoblast gene activation induced by the S252W fibroblast growth factor receptor 2 mutation in Apert craniosynostosis

1 reference

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1 reference

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Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.

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2 September 2018

Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse

1 reference

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2 September 2018

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1 reference

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2 September 2018

The Ser252Trp fibroblast growth factor receptor-2 (FGFR-2) mutation induces PKC-independent downregulation of FGFR-2 associated with premature calvaria osteoblast differentiation

1 reference

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1 reference

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p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix

1 reference

https://pubmed.ncbi.nlm.nih.gov/24489893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24489893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24489893

12 December 2020

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inferred from PubMed ID database lookup

Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/24489893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0087311

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

2014PLoSO...987311C

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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