(Q28513627)

25 January 2017

title

Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis (English)

1 reference

Collagen, type I, alpha 2

25 January 2017

main subject

1 reference

Fibroblast growth factor receptor 3

1 reference

Mitogen-activated protein kinase 14

1 reference

Mitogen-activated protein kinase 3

1 reference

Mitogen-activated protein kinase 1

1 reference

5

Huabing Qi

1 reference

25 January 2017

Nan Su

1

1 reference

25 January 2017

Qidi Sun

2

1 reference

25 January 2017

Can Li

3

1 reference

25 January 2017

Xiumin Lu

4

1 reference

25 January 2017

Siyu Chen

6

1 reference

25 January 2017

Jing Yang

7

1 reference

25 January 2017

Xiaolan Du

8

1 reference

25 January 2017

Ling Zhao

9

1 reference

25 January 2017

Qifen He

10

1 reference

25 January 2017

Min Jin

11

1 reference

25 January 2017

Yue Shen

12

1 reference

25 January 2017

Di Chen

13

1 reference

25 January 2017

Lin Chen

14

1 reference

25 January 2017

publication date

1 April 2010

1 reference

25 January 2017

published in

Human Molecular Genetics

1 reference

25 January 2017

volume

19

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25 January 2017

issue

7

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25 January 2017

page(s)

1199–1210

1 reference

A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome

25 January 2017

cites work

1 reference

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Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

19 March 2017

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Fibroblast growth factor receptor 3 mutations in achondroplasia and related forms of dwarfism

19 March 2017

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Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10

19 March 2017

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Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3

19 March 2017

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Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)

19 March 2017

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

7 April 2017

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29 September 2017

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29 September 2017

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Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.

29 September 2017

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Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

29 September 2017

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Osteoclast differentiation and gene regulation

29 September 2017

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Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation

29 September 2017

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TGF-beta2 stimulates cranial suture closure through activation of the Erk-MAPK pathway

29 September 2017

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Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling

29 September 2017

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FGF signaling in the developing endochondral skeleton

29 September 2017

1 reference

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Molecules mimicking Smad1 interacting with Hox stimulate bone formation

29 September 2017

1 reference

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Fibroblast growth factor signaling controlling osteoblast differentiation

29 September 2017

1 reference

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Activation of p38 Mitogen-Activated Protein Kinase Is Required for Osteoblast Differentiation

29 September 2017

1 reference

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Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Minireview: the OPG/RANKL/RANK system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Establishment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation

29 September 2017

1 reference

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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

29 September 2017

1 reference

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MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis

29 September 2017

1 reference

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

29 September 2017

1 reference

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A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

A recurrent mutation, ala391glu, in the transmembrane region of FGFR3 causes Crouzon syndrome and acanthosis nigricans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Crouzon with acanthosis nigricans. Further delineation of the syndrome.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Erk pathways negatively regulate matrix mineralization

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Prenatal diagnosis of achondroplasia presenting with multiple-suture synostosis: a novel association

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Osteogenic and chondrogenic differentiation of embryonic stem cells in response to specific growth factors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Defective bone mineralization and osteopenia in young adult FGFR3-/- mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

FGF signaling in skeletal development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115638

Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation

27 November 2018

1 reference

12 December 2020

Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop

1 reference

12 December 2020

Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures

1 reference

12 December 2020

Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42/p44 MAP kinase

1 reference

12 December 2020

Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDP590

1 reference

1 reference

1 reference

1 reference