(Q37527451)

20 August 2017

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title

Alternative strategies for toxicity testing of species-specific biopharmaceuticals (English)

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20 August 2017

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Jeanine L Bussiere

1

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20 August 2017

Pauline Martin

2

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20 August 2017

Michelle Horner

3

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20 August 2017

Jessica Couch

4

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20 August 2017

Meghan Flaherty

5

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20 August 2017

Laura Andrews

6

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20 August 2017

Joseph Beyer

7

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20 August 2017

Christopher Horvath

8

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20 August 2017

publication date

1 May 2009

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International Journal of Toxicology

20 August 2017

published in

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20 August 2017

volume

28

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20 August 2017

issue

3

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20 August 2017

page(s)

230-253

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Preclinical safety evaluation of biotechnology-derived pharmaceuticals

20 August 2017

cites work

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https://api.crossref.org/works/10.1177%2F1091581809337262

Species differences in the structure and function of the immune system

21 January 2018

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Of mice and not men: differences between mouse and human immunology

21 January 2018

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https://api.crossref.org/works/10.1177%2F1091581809337262

Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Induction of direct antimicrobial activity through mammalian toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Differential effects of morphine and naltrexone on the antibody response in various mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Anti-KC autoantibody:KC complexes cause severe lung inflammation in mice via IgG receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Reproductive effects of chronic administration of murine interferon-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Utilization of homologous proteins to evaluate the safety of recombinant human proteins--case study: recombinant human interferon-gamma (rhIFN-gamma)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

A comparison of placental development and endocrine functions between the human and mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Safety issues specific to clinical development of protein therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

The beginning of the end for chimpanzee experiments?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Effects of administration of a monoclonal antibody against mouse tumor necrosis factor alpha during pregnancy and lactation on the pre- and postnatal development of the mouse immune system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Practical aspects of including functional endpoints in developmental toxicity studies. Case study: immune function in HuCD4 transgenic mice exposed to anti-CD4 MAb in utero.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

A comparison of effects on reproduction and neonatal development in cynomolgus monkeys given human soluble IL-4R and mice given murine soluble IL-4R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Lymphotoxin/light, lymphoid microenvironments and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Human carcinogenic risk evaluation: an alternative approach to the two-year rodent bioassay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Recombinant rat and mouse growth hormones: risk assessment of carcinogenic potential in 2-year bioassays in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Carcinogenicity testing of IL-10: principles and practicalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1091581809337262

21 January 2018

Identifiers

DOI

10.1177/1091581809337262

1 reference

20 August 2017

1 reference