(Q34590536)

3 August 2017

1 reference

title

Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio (English)

1 reference

3 August 2017

1 reference

Brad Bolon

1

1 reference

PubMed ID

11936900

3 August 2017

Elizabeth Galbreath

series ordinal

2

1 reference

3 August 2017

1 January 2002

1 reference

International Journal of Toxicology

3 August 2017

1 reference

3 August 2017

21

1 reference

3 August 2017

1

1 reference

3 August 2017

55-64

1 reference

Cre-mediated somatic site-specific recombination in mice

3 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Use of transgenic mouse lacI/Z mutation assays in genetic toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Adenovirus-mediated gene transfer during initial organogenesis in the mammalian embryo is promoter-dependent and tissue-specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Going the distance: a current view of enhancer action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Dermal carcinogenicity in transgenic mice: relative responsiveness of male and female hemizygous and homozygous Tg.AC mice to 12-O-tetradecanoylphorbol 13-acetate (TPA) and benzene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Comparative and correlative neuroanatomy for the toxicologic pathologist

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

A defect in nurturing in mice lacking the immediate early gene fosB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Neuropathogenic actions of cytokines assessed in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Structural and functional impact of the transgenic expression of cytokines in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Altering the genome by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Chromosomal position effects and the modulation of transgene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transgenic mice as future tools in risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Female embryonic lethality in mice nullizygous for both Msh2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

RANK is essential for osteoclast and lymph node development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Nongenomic transmission across generations of maternal behavior and stress responses in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transgenesis by means of blastocyst-derived embryonic stem cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Pathophysiology of gene-targeted mouse models for cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

High resolution MRI and MRS: a feasibility study for the investigation of focal cerebral ischemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Rescue of angiotensinogen-knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Altering genes in animals by gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Near-microscopic magnetic resonance imaging of the brains of phenylalanine hydroxylase-deficient mice, normal littermates, and of normal BALB/c mice at 9.4 Tesla.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Generation and reproductive phenotypes of mice lacking estrogen receptor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Qualitative and quantitative decline in spermatogenesis of the follicle-stimulating hormone receptor knockout (FORKO) mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Inducible gene targeting in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Reinforcing and neurochemical effects of cocaine: differences among C57, DBA, and 129 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

In vivo analysis of Pim-1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

An adenovirus vector for gene transfer into neurons and glia in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Differential Gene Expression of Renin and Angiotensinogen in the TGR(mREN-2)27 Transgenic Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transgenic animals in the evaluation of compound efficacy and toxicity: will they be as useful as they are novel?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Maternal care, hippocampal synaptogenesis and cognitive development in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

In vivo visualization of gene expression using magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

The use of genetically modified animals in carcinogenicity bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Legless, a Novel Mutation Found in PHT1-1 Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transgenic animal models for measuring mutations in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Targeted mutagenesis: analysis of phenotype without germ line transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Increased anxiety of mice lacking the serotonin1A receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Regulated expression of foreign genes in vivo after germline transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Complications associated with genetic background effects in research using knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transgenic mice in drug dependence research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Serotonin receptor 1A knockout: an animal model of anxiety-related disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Viral vectors for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Genome manipulation in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Genetically modified animals in pharmacological research: future trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Impact of knockout mice in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Temporally and spatially regulated somatic mutagenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Genetic knockouts in mice: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Gene disruption in mice: models of development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Initial experiences and future directions for transgenic mouse mutation assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

FVB/N: an inbred mouse strain preferable for transgenic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

An inbred colony of oncogene transgenic mice: diversity of tumours and potential as a therapeutic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Subregion- and cell type-restricted gene knockout in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Transgenesis by adenovirus-mediated gene transfer into mouse zona-free eggs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

A transgenic mouse expressing human CYP1A2 in the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Quantification of target gene expression by imaging reporter gene expression in living animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Magnetic resonance microscopy of the C57BL mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Maternal age and traits in offspring

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

Non-injection methods for the production of embryonic stem cell-embryo chimaeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810252826019

10.1080/10915810252826019

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11936900