(Q37529522)

20 August 2017

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title

The molecular mechanism of induced pluripotency: a two-stage switch (English)

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20 August 2017

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Wouter Scheper

1

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20 August 2017

Sjef Copray

series ordinal

2

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20 August 2017

publication date

24 June 2009

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Stem Cell Reviews and Reports

20 August 2017

published in

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20 August 2017

volume

5

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20 August 2017

issue

3

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20 August 2017

page(s)

204-223

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Promotion of reprogramming to ground state pluripotency by signal inhibition

20 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS12015-009-9077-X

Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12015-009-9077-X

Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12015-009-9077-X

Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12015-009-9077-X

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

21 January 2018

1 reference

12 December 2020

Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest

1 reference

12 December 2020

Suppression of non-small cell lung tumor development by the let-7 microRNA family

1 reference

12 December 2020

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

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12 December 2020

A high-efficiency system for the generation and study of human induced pluripotent stem cells

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12 December 2020

Induced pluripotent stem cells generated without viral integration

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12 December 2020

Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression

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12 December 2020

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

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12 December 2020

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

1 reference

12 December 2020

Reprogramming of human somatic cells to pluripotency with defined factors

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12 December 2020

Core transcriptional regulatory circuitry in human embryonic stem cells

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12 December 2020

Oct4 is required for primordial germ cell survival

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12 December 2020

Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors

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12 December 2020

Strategies and new developments in the generation of patient-specific pluripotent stem cells

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12 December 2020

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

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12 December 2020

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

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12 December 2020

A core Klf circuitry regulates self-renewal of embryonic stem cells.

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12 December 2020

Stem cells: 5 things to know before jumping on the iPS bandwagon

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12 December 2020

A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells

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12 December 2020

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

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12 December 2020

Multipotent cell lineages in early mouse development depend on SOX2 function

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12 December 2020

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein

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12 December 2020

Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.

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12 December 2020

Reprogramming of pancreatic beta cells into induced pluripotent stem cells

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12 December 2020

Role of the murine reprogramming factors in the induction of pluripotency

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12 December 2020

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

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12 December 2020

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin

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12 December 2020

Induced pluripotent stem cells from a spinal muscular atrophy patient

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12 December 2020

Generation of germline-competent induced pluripotent stem cells

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12 December 2020

Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

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12 December 2020

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

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12 December 2020

Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts

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12 December 2020

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression

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12 December 2020

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

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12 December 2020

OCT4: biological functions and clinical applications as a marker of germ cell neoplasia

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12 December 2020

Generation of human induced pluripotent stem cells from dermal fibroblasts

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12 December 2020

Reprogramming of murine and human somatic cells using a single polycistronic vector

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12 December 2020

Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome

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12 December 2020

A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal

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12 December 2020

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.

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12 December 2020

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways

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12 December 2020

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

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12 December 2020

Polycomb complexes repress developmental regulators in murine embryonic stem cells

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12 December 2020

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

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12 December 2020

Capturing pluripotency

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12 December 2020

Wnt signaling promotes reprogramming of somatic cells to pluripotency

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12 December 2020

A chromatin landmark and transcription initiation at most promoters in human cells

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12 December 2020

The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology

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12 December 2020

Oct-3/4 is a dose-dependent oncogenic fate determinant

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12 December 2020

Nanog safeguards pluripotency and mediates germline development

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12 December 2020

The c-Myc target gene network

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12 December 2020

The ARF tumor suppressor: keeping Myc on a leash.

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12 December 2020

Generation of mouse induced pluripotent stem cells without viral vectors

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12 December 2020

Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach

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12 December 2020

Dissecting direct reprogramming through integrative genomic analysis

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12 December 2020

Widespread microRNA repression by Myc contributes to tumorigenesis

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12 December 2020

Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle

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12 December 2020

Network motifs: theory and experimental approaches

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12 December 2020

Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development

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12 December 2020

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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12 December 2020

Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions

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12 December 2020

let-7 regulates self renewal and tumorigenicity of breast cancer cells

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12 December 2020

c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

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12 December 2020

The molecular mechanism of embryonic stem cell pluripotency and self-renewal

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12 December 2020

From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion

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12 December 2020

Transcriptional regulation of nanog by OCT4 and SOX2.

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12 December 2020

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

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12 December 2020

Mechanism of transcriptional activation by the Myc oncoproteins

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12 December 2020

Stochastic mechanisms in gene expression

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12 December 2020

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

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12 December 2020

Non-transcriptional control of DNA replication by c-Myc

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12 December 2020

Analysis of genomic targets reveals complex functions of MYC.

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12 December 2020

Generation of insulin-secreting islet-like clusters from human skin fibroblasts

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12 December 2020

The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter

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12 December 2020

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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12 December 2020

The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells.

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12 December 2020

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

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12 December 2020

Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors

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12 December 2020

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells

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12 December 2020

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors

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12 December 2020

The first direct reprogramming of adult human fibroblasts

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12 December 2020

KLF4, p21 and context-dependent opposing forces in cancer

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12 December 2020

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.

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12 December 2020

Increase of GKLF messenger RNA and protein expression during progression of breast cancer

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12 December 2020

Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells

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12 December 2020

The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors

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12 December 2020

Induced pluripotent stem cell lines derived from human somatic cells

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12 December 2020

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

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12 December 2020

Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells

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12 December 2020

Oct-4: control of totipotency and germline determination

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12 December 2020

Mediators of reprogramming: transcription factors and transitions through mitosis

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12 December 2020

Generation of induced pluripotent stem cells using recombinant proteins

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12 December 2020

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency

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12 December 2020

DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation.

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12 December 2020

BMP4 initiates human embryonic stem cell differentiation to trophoblast

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12 December 2020

Cancer therapeutics: targeting the dark side of Myc.

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12 December 2020

Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages

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12 December 2020

The reprogramming language of pluripotency

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12 December 2020

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse

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12 December 2020

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12 December 2020

Phenotypic correction of murine hemophilia A using an iPS cell-based therapy

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12 December 2020

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

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12 December 2020

Oct4-induced pluripotency in adult neural stem cells.

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12 December 2020

Emerging role of KLF4 in human gastrointestinal cancer

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12 December 2020

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

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12 December 2020

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette

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12 December 2020

Generation of pluripotent stem cells from adult mouse liver and stomach cells

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12 December 2020

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

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12 December 2020

Functional cardiomyocytes derived from human induced pluripotent stem cells

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12 December 2020

The undoing of differentiation by four defined factors: A big step forward towards generating patient specific pluripotent stem cells

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12 December 2020

Oct-4: gatekeeper in the beginnings of mammalian development.

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12 December 2020

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

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12 December 2020

Negative autoregulation speeds the response times of transcription networks

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12 December 2020

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

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12 December 2020

Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression

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12 December 2020

Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

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12 December 2020

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

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12 December 2020

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

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12 December 2020

Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells

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12 December 2020

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

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12 December 2020

Myc influences global chromatin structure.

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12 December 2020

High-efficiency RNA interference in human embryonic stem cells

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12 December 2020

Direct activation of TERT transcription by c-MYC.

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12 December 2020

The biology of the mammalian Krüppel-like family of transcription factors

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12 December 2020

Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

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12 December 2020

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

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12 December 2020

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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12 December 2020

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

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12 December 2020

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

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12 December 2020

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

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12 December 2020

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

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12 December 2020

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer

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12 December 2020

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

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12 December 2020

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells

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12 December 2020

Gene expression in human embryonic stem cell lines: unique molecular signature

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12 December 2020

Klf4 is a transcription factor required for establishing the barrier function of the skin

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12 December 2020

Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3

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12 December 2020

Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states

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12 December 2020

Induced pluripotency with endogenous and inducible genes

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12 December 2020

How is pluripotency determined and maintained?

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12 December 2020

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12 December 2020

A protein interaction network for pluripotency of embryonic stem cells

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12 December 2020

Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans

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12 December 2020

Generation of induced pluripotent stem cells in the absence of drug selection

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12 December 2020

A combined chemical and genetic approach for the generation of induced pluripotent stem cells

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12 December 2020

New Myc-anisms for DNA replication and tumorigenesis?

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12 December 2020

Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

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12 December 2020

Disease-specific induced pluripotent stem cells

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12 December 2020

A fresh look at iPS cells

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12 December 2020

Chromatin signatures of pluripotent cell lines

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12 December 2020

10.1007/S12015-009-9077-X

Identifiers

DOI

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20 August 2017

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