(Q34478868)

2 August 2017

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title

KLF4, p21 and context-dependent opposing forces in cancer (English)

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2 August 2017

2

Daniel S Peeper

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2 August 2017

Benjamin D Rowland

1

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2 August 2017

language of work or name

English

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publication date

1 January 2006

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2 August 2017

published in

Nature Reviews Cancer

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2 August 2017

volume

6

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2 August 2017

issue

1

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2 August 2017

page(s)

11-23

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https://scigraph.springernature.com/pub.10.1038/nrc1780

2 August 2017

exact match

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cites work

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The RUNX genes: gain or loss of function in cancer

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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

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Mammalian Krüppel-like transcription factors: more than just a pretty finger

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A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

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Mammalian SP/KLF transcription factors: bring in the family

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KLF6, a candidate tumor suppressor gene mutated in prostate cancer

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Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

31 March 2020

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KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1.

31 March 2020

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Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis

31 March 2020

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Intestinal tumor progression is associated with altered function of KLF5

31 March 2020

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Developmental expression of mouse Krüppel-like transcription factor KLF7 suggests a potential role in neurogenesis

31 March 2020

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

31 March 2020

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WAF1, a potential mediator of p53 tumor suppression

31 March 2020

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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

31 March 2020

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

31 March 2020

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The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter

31 March 2020

1 reference

Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle

31 March 2020

1 reference

Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest

31 March 2020

1 reference

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

31 March 2020

1 reference

Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation

31 March 2020

1 reference

Klf4 is a transcription factor required for establishing the barrier function of the skin

31 March 2020

1 reference

Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis

31 March 2020

1 reference

Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients

31 March 2020

1 reference

Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

31 March 2020

1 reference

Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation

31 March 2020

1 reference

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

31 March 2020

1 reference

Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression

31 March 2020

1 reference

Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach

31 March 2020

1 reference

Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.

31 March 2020

1 reference

p21 is a universal inhibitor of cyclin kinases

31 March 2020

1 reference

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

31 March 2020

1 reference

The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact

31 March 2020

1 reference

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

31 March 2020

1 reference

Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect

31 March 2020

1 reference

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

31 March 2020

1 reference

Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent.

31 March 2020

1 reference

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

31 March 2020

1 reference

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

31 March 2020

1 reference

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

31 March 2020

1 reference

p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

31 March 2020

1 reference

Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon

31 March 2020

1 reference

New genes involved in cancer identified by retroviral tagging

31 March 2020

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Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia

31 March 2020

1 reference

Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer

31 March 2020

1 reference

Compromised HOXA5 function can limit p53 expression in human breast tumours

31 March 2020

1 reference

Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage

31 March 2020

1 reference

Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.

31 March 2020

1 reference

Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene

31 March 2020

1 reference

A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression

31 March 2020

1 reference

Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain

31 March 2020

1 reference

A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

31 March 2020

1 reference

Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.

31 March 2020

1 reference

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

1 reference

The ornithine decarboxylase gene is a transcriptional target of c-Myc

31 March 2020

1 reference

Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells

31 March 2020

1 reference

Negative regulation of the mammalian UV response by Myc through association with Miz-1

31 March 2020

1 reference

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

31 March 2020

1 reference

CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

1 reference

The adenoviral E1A oncoproteins interfere with the growth-inhibiting effect of the cdk-inhibitor p21(CIP1/WAF1).

31 March 2020

1 reference

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

31 March 2020

1 reference

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

31 March 2020

1 reference

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

31 March 2020

1 reference

Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction

31 March 2020

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

1 reference

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

31 March 2020

1 reference

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

31 March 2020

1 reference

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

31 March 2020

1 reference

New functional activities for the p21 family of CDK inhibitors

31 March 2020

1 reference

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

31 March 2020

1 reference

Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues

31 March 2020

1 reference

A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase

31 March 2020

1 reference

Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?

31 March 2020

1 reference

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

31 March 2020

1 reference

Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

31 March 2020

1 reference

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

31 March 2020

1 reference

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

31 March 2020

1 reference

Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis

31 March 2020

1 reference

Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

31 March 2020

1 reference

G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression

31 March 2020

1 reference

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

31 March 2020

1 reference

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

31 March 2020

1 reference

Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard

31 March 2020

1 reference

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

1 reference

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

1 reference

Prospective identification of tumorigenic breast cancer cells

31 March 2020

1 reference

Identification of bronchioalveolar stem cells in normal lung and lung cancer

31 March 2020

1 reference

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

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RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.

31 March 2020

1 reference

Causal relationship between the loss of RUNX3 expression and gastric cancer

31 March 2020

1 reference

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

31 March 2020

1 reference

Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype.

31 March 2020

1 reference

p21(WAF1/CIP1) mediates the growth response to TGF-beta in human epithelial cells

31 March 2020

1 reference

Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury.

31 March 2020

1 reference

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

31 March 2020

1 reference

KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells

31 March 2020

1 reference

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling

31 March 2020

1 reference

Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.

31 March 2020

1 reference

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

31 March 2020

1 reference

Control of endodermal endocrine development by Hes-1

31 March 2020

1 reference

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

31 March 2020

1 reference

Requirement of Math1 for secretory cell lineage commitment in the mouse intestine

31 March 2020

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Notch signals control the fate of immature progenitor cells in the intestine

31 March 2020

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Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.

31 March 2020

1 reference

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein

31 March 2020

1 reference

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

31 March 2020

1 reference

p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

31 March 2020

1 reference

31 March 2020

1 reference

RAS oncogenes: the first 30 years.

31 March 2020

1 reference

Wildtype Kras2 can inhibit lung carcinogenesis in mice

31 March 2020

1 reference

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

31 March 2020

1 reference

Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites

31 March 2020

1 reference

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

31 March 2020

1 reference

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

31 March 2020

1 reference

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

31 March 2020

1 reference

Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif

31 March 2020

1 reference

The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells

31 March 2020

1 reference

Kruppel-like factor 4 regulates laminin alpha 3A expression in mammary epithelial cells

31 March 2020

1 reference

Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage

31 March 2020

1 reference

Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1

31 March 2020

1 reference

The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells

31 March 2020

1 reference

Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor

31 March 2020

1 reference

Transactivation of the human keratin 4 and Epstein-Barr virus ED-L2 promoters by gut-enriched Krüppel-like factor

31 March 2020

1 reference

Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements

31 March 2020

1 reference

Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation

31 March 2020

1 reference

The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion

31 March 2020

1 reference

Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor

31 March 2020

1 reference

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

31 March 2020

1 reference

Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor

31 March 2020

1 reference

Novel polymorphism in p21(waf1/cip1) cyclin dependent kinase inhibitor gene: association with human esophageal cancer

31 March 2020

1 reference

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

31 March 2020

1 reference

Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation

31 March 2020

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p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human T-cell leukemia virus type 1-encoded tax.

31 March 2020

1 reference

Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

31 March 2020

1 reference

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

31 March 2020

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

31 March 2020

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

31 March 2020

1 reference

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

31 March 2020

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Smad3 mutant mice develop metastatic colorectal cancer

31 March 2020

1 reference

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

31 March 2020

1 reference

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

31 March 2020

1 reference

RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53.

31 March 2020

1 reference

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

31 March 2020

1 reference

Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

31 March 2020

1 reference

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

31 March 2020

1 reference

A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc

31 March 2020

1 reference

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.

31 March 2020

1 reference

Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells.

31 March 2020

1 reference

Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing

31 March 2020

1 reference

Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms.

31 March 2020

1 reference

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

31 March 2020

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Notch1 functions as a tumor suppressor in mouse skin

31 March 2020

1 reference

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

31 March 2020

1 reference

Amplification and overexpression of E2F3 in human bladder cancer

31 March 2020

1 reference

Tumor induction and tissue atrophy in mice lacking E2F-1

31 March 2020

1 reference

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.

31 March 2020

1 reference

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

31 March 2020

1 reference

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

31 March 2020

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p53 and E2F-1 cooperate to mediate apoptosis

31 March 2020

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

31 March 2020

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

31 March 2020

1 reference

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

31 March 2020

1 reference

Oncogenic capacity of the E2F1 gene

31 March 2020

1 reference

Multiple members of the E2F transcription factor family are the products of oncogenes

31 March 2020

1 reference

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

31 March 2020

1 reference

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

31 March 2020

1 reference

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

31 March 2020

1 reference

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

31 March 2020

1 reference

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

31 March 2020

1 reference

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

31 March 2020

1 reference

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

31 March 2020

1 reference

Identification of the von Hippel-Lindau disease tumor suppressor gene

31 March 2020

1 reference

Mutations of the VHL tumour suppressor gene in renal carcinoma

31 March 2020

1 reference

Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

31 March 2020

1 reference

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

31 March 2020

1 reference

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

31 March 2020

1 reference

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1780

1 reference

Dimensions Publication ID

2 August 2017

1053134180

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