(Q37542425)

20 August 2017

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title

The impact of synthetic biology on drug discovery (English)

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20 August 2017

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2

Martin Fussenegger

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20 August 2017

1

Wilfried Weber

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20 August 2017

publication date

4 July 2009

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20 August 2017

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20 August 2017

volume

14

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20 August 2017

issue

19-20

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20 August 2017

page(s)

956-963

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Synthetic ecosystems based on airborne inter- and intrakingdom communication

20 August 2017

cites work

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12 December 2020

Female-specific insect lethality engineered using alternative splicing.

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12 December 2020

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

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12 December 2020

The second wave of synthetic biology: from modules to systems

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12 December 2020

An engineered epigenetic transgene switch in mammalian cells

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12 December 2020

Mutations of the Igbeta gene cause agammaglobulinemia in man.

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12 December 2020

Preventing biofilms of clinically relevant organisms using bacteriophage

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12 December 2020

ABC transporters and inhibitors: new targets, new agents.

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12 December 2020

Genetic design: rising above the sequence

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12 December 2020

One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome

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12 December 2020

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

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12 December 2020

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

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12 December 2020

Systems biology approaches to bioremediation

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12 December 2020

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

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12 December 2020

Gene synthesis demystified

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12 December 2020

Characterization of the 1918 influenza virus polymerase genes

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12 December 2020

Macrolide-based transgene control in mammalian cells and mice

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12 December 2020

Mammalian synthetic biology: engineering of sophisticated gene networks

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12 December 2020

Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis

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12 December 2020

A linguistic model for the rational design of antimicrobial peptides.

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12 December 2020

Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

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12 December 2020

A synthetic oscillatory network of transcriptional regulators

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12 December 2020

Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients

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12 December 2020

Defossiling fuel: how synthetic biology can transform biofuel production

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12 December 2020

Inhibition of mutation and combating the evolution of antibiotic resistance

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12 December 2020

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

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12 December 2020

Drug discovery beyond the 'rule-of-five'.

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12 December 2020

Streptogramin-based gene regulation systems for mammalian cells

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12 December 2020

A coumermycin/novobiocin-regulated gene expression system

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12 December 2020

Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis

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12 December 2020

A synthetic mammalian gene circuit reveals antituberculosis compounds

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12 December 2020

Engineering and applications of genetic circuits

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12 December 2020

Infectious diseases. Source of new hope against malaria is in short supply

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12 December 2020

In vitro assays for anticancer drug discovery--a novel approach based on engineered mammalian cell lines

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12 December 2020

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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12 December 2020

Drug-sensing hydrogels for the inducible release of biopharmaceuticals

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12 December 2020

A novel mammalian cell-based approach for the discovery of anticancer drugs with reduced cytotoxicity on non-dividing cells

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12 December 2020

Synthetic biology for synthetic chemistry

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12 December 2020

Bacteriophage Therapy

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12 December 2020

Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies

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12 December 2020

Virus attenuation by genome-scale changes in codon pair bias

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12 December 2020

EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator

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12 December 2020

Targeted development of registries of biological parts

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12 December 2020

A fast, robust and tunable synthetic gene oscillator.

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12 December 2020

Construction of a genetic toggle switch in Escherichia coli

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12 December 2020

Intron length increases oscillatory periods of gene expression in animal cells

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12 December 2020

Production of isoprenoid pharmaceuticals by engineered microbes

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12 December 2020

A synthetic time-delay circuit in mammalian cells and mice

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12 December 2020

Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics

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12 December 2020

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

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12 December 2020

Insect population control using a dominant, repressible, lethal genetic system.

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12 December 2020

Engineering of synthetic mammalian gene networks

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12 December 2020

Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics

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12 December 2020

Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli

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12 December 2020

Diversity-based, model-guided construction of synthetic gene networks with predicted functions

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12 December 2020

An amino acid substitution in a capsid protein enhances phage survival in mouse circulatory system more than a 1000-fold.

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12 December 2020

Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration

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12 December 2020

A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches

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12 December 2020

Environmentally controlled invasion of cancer cells by engineered bacteria

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12 December 2020

A synthetic multicellular system for programmed pattern formation

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12 December 2020

Refinement and standardization of synthetic biological parts and devices

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12 December 2020

Dispersing biofilms with engineered enzymatic bacteriophage

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12 December 2020

Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice

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12 December 2020

Guiding bacteria with small molecules and RNA.

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12 December 2020

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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12 December 2020

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

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12 December 2020

Bioengineering novel in vitro metabolic pathways using synthetic biology

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12 December 2020

Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery

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12 December 2020

Malaria control with genetically manipulated insect vectors

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12 December 2020

Characterization of the reconstructed 1918 Spanish influenza pandemic virus

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12 December 2020

A tunable synthetic mammalian oscillator

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12 December 2020

10.1016/J.DRUDIS.2009.06.010

Identifiers

DOI

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20 August 2017

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