(Q37544439)

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Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

object named as

John P Newnham

8

0 references

object named as

Jeffrey A Keelan

1

0 references

author name string

Matthew W Kemp

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Matthew S Payne

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

David Johnson

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Sarah J Stock

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Masatoshi Saito

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Prabhavathi Fernandes

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

0 references

publication date

4 November 2013

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

58

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

447-454

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Fetal safety of macrolides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Randomized, double-blind, multicenter phase 2 study comparing the efficacy and safety of oral solithromycin (CEM-101) to those of oral levofloxacin in the treatment of patients with community-acquired bacterial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Antibiotics for treating bacterial vaginosis in pregnancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Antimicrobials for preterm birth prevention: an overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: do the diagnostic criteria for preterm labor need to be changed?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Molecular characterization of off-target activities of telithromycin: a potential role for nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

CEM-101 activity against Gram-positive organisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Excretion of biliary compounds during intrauterine life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

The effect of second-trimester antibiotic therapy on the rate of preterm birth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Animal models of human placentation--a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Pregnancy outcome following gestational exposure to azithromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Antibiotics for treating bacterial vaginosis in pregnancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Intrauterine infection and preterm delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

23 August 2017

Antibiotics in the management of PROM and preterm labor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

6 September 2017

Diversity of microbes in amniotic fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

6 September 2017

Pharmacological inhibition of inflammatory pathways for the prevention of preterm birth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

6 September 2017

Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

14 September 2017

Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

14 September 2017

The risk of intra-amniotic infection, inflammation and histologic chorioamnionitis in term pregnant women with intact membranes and labor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

1 September 2018

The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

1 September 2018

Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

1 September 2018

Maternal and transplacental pharmacokinetics of azithromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

1 September 2018

Antibiotics for preterm rupture of membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910757

5 November 2018

Maternal Administration of Erythromycin Fails to Eradicate Intrauterine Ureaplasma Infection in an Ovine Model1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The placental transfer of erythomycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplacental passage of erythromycin and clindamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic uptake and excretion of [14C]sodium taurocholate by the isolated perfused fetal sheep liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24189250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.01743-13

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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