(Q37550780)

English

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis

scientific article published on July 2008

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

21 August 2017

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis (English)

1 reference

Europe PubMed Central

21 August 2017

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

H. Frederik Nijhout

9

object named as

H Frederik Nijhout

1 reference

Europe PubMed Central

21 August 2017

Marian L Neuhouser

2

object named as

Marian Neuhouser

1 reference

Europe PubMed Central

21 August 2017

8

object named as

Michael C Reed

1 reference

Europe PubMed Central

21 August 2017

author name string

Cornelia M Ulrich

1

1 reference

Europe PubMed Central

21 August 2017

Amy Y Liu

3

1 reference

Europe PubMed Central

21 August 2017

Alanna Boynton

4

1 reference

Europe PubMed Central

21 August 2017

Jesse F Gregory

5

1 reference

Europe PubMed Central

21 August 2017

Barry Shane

6

1 reference

Europe PubMed Central

21 August 2017

S Jill James

7

1 reference

Europe PubMed Central

21 August 2017

publication date

1 July 2008

1 reference

Europe PubMed Central

21 August 2017

Cancer Epidemiology, Biomarkers & Prevention

1 reference

Europe PubMed Central

21 August 2017

17

1 reference

Europe PubMed Central

21 August 2017

7

1 reference

Europe PubMed Central

21 August 2017

1822-1831

1 reference

Europe PubMed Central

21 August 2017

Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Folate and cancer--timing is everything

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Nutrigenetics in cancer research--folate metabolism and colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Will mandatory folic acid fortification prevent or promote cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Physiology of folate and vitamin B12 in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Colon Cancer and Genetic Variation in Folate Metabolism: The Clinical Bottom Line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Folate status: effects on pathways of colorectal carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

23 August 2017

Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

14 September 2017

In silico experimentation with a model of hepatic mitochondrial folate metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

25 June 2018

Tissue distribution and prediction of total body folate of rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

25 June 2018

Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Effect of interaction between adherence to a Mediterranean diet and the methylenetetrahydrofolate reductase 677C-->T mutation on homocysteine concentrations in healthy adults: the ATTICA Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C mutations are associated with DNA hypomethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Age and Gender Affect the Relation between Methylenetetrahydrofolate Reductase C677T Genotype and Fasting Plasma Homocysteine Concentrations in the Framingham Offspring Study Cohort

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) cohort.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Folate levels in human liver from autopsies in Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912564

1 September 2018

Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate and carcinogenesis: evidence, mechanisms, and implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1055-9965.EPI-07-2937

1 reference

Europe PubMed Central

21 August 2017

release_eqaj34tqb5dz3bmbxf44cwq6gm

1 reference

https://api.fatcat.wiki/v0/release/eqaj34tqb5dz3bmbxf44cwq6gm

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

21 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q37550780&oldid=2075738786"