(Q37573385)

21 August 2017

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title

RecQ helicases: multifunctional genome caretakers (English)

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21 August 2017

Wai Kit Chu

1

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PubMed ID

19657341

21 August 2017

Ian D Hickson

series ordinal

2

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PubMed ID

19657341

21 August 2017

language of work or name

English

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publication date

6 August 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

644-654

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21 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc2682

21 August 2017

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cites work

Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae

1 reference

Unwinding the 'Gordian knot' of helicase action.

21 January 2018

1 reference

DNA helicases required for homologous recombination and repair of damaged replication forks

31 March 2020

1 reference

Molecular genetics of RecQ helicase disorders

31 March 2020

1 reference

RecQ helicases: guardian angels of the DNA replication fork

31 March 2020

1 reference

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli

31 March 2020

1 reference

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

31 March 2020

1 reference

The RecQ gene family in plants

31 March 2020

1 reference

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta

31 March 2020

1 reference

Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase

31 March 2020

1 reference

Structure and function of RecQ DNA helicases

31 March 2020

1 reference

Pathways and functions of the Werner syndrome protein

31 March 2020

1 reference

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

31 March 2020

1 reference

Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family

31 March 2020

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Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA

31 March 2020

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Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I

31 March 2020

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High-resolution structure of the E.coli RecQ helicase catalytic core

31 March 2020

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Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.

31 March 2020

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Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

31 March 2020

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Human premature aging, DNA repair and RecQ helicases

31 March 2020

1 reference

Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification

31 March 2020

1 reference

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification

31 March 2020

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Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

31 March 2020

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Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

31 March 2020

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Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.

31 March 2020

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RecQ helicases: caretakers of the genome

31 March 2020

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Caretaker tumour suppressor genes that defend genome integrity

31 March 2020

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Werner syndrome protein limits MYC-induced cellular senescence

31 March 2020

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The Bloom's syndrome gene product is homologous to RecQ helicases

31 March 2020

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Positional cloning of the Werner's syndrome gene

31 March 2020

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Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

31 March 2020

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Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases

31 March 2020

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Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene

31 March 2020

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Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry

31 March 2020

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Carrier frequency of the Bloom syndrome blmAsh mutation in the Ashkenazi Jewish population

31 March 2020

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The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry

31 March 2020

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CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN

31 March 2020

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A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

31 March 2020

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Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

31 March 2020

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Cancer predisposition caused by elevated mitotic recombination in Bloom mice

31 March 2020

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Chromosome instability and tumor predisposition inversely correlate with BLM protein levels

31 March 2020

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Enhanced tumor formation in mice heterozygous for Blm mutation

31 March 2020

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Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts

31 March 2020

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Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

31 March 2020

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A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

31 March 2020

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Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue.

31 March 2020

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Mutations in the WRN gene in mice accelerate mortality in a p53-null background

31 March 2020

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Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet.

31 March 2020

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

31 March 2020

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The mutation spectrum in RECQL4 diseases

31 March 2020

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Clonal lines of aneuploid cells in Rothmund-Thomson syndrome

31 March 2020

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Rothmund-Thomson syndrome associated with trisomy 8 mosaicism

31 March 2020

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Instability of lymphocyte chromosomes in a girl with Rothmund-Thomson syndrome

31 March 2020

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Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome

31 March 2020

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[Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases]

31 March 2020

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Growth retardation and skin abnormalities of the Recql4-deficient mouse.

31 March 2020

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Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome

31 March 2020

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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

31 March 2020

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Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

31 March 2020

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Escherichia coli RecQ protein is a DNA helicase

31 March 2020

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Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.

31 March 2020

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Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

31 March 2020

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The Bloom's syndrome helicase unwinds G4 DNA

31 March 2020

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The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

31 March 2020

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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

31 March 2020

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The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

31 March 2020

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Analysis of helicase activity and substrate specificity of Drosophila RECQ5

31 March 2020

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RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

31 March 2020

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RecQ helicases: suppressors of tumorigenesis and premature aging.

31 March 2020

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The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

31 March 2020

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A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

31 March 2020

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RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

31 March 2020

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Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4

31 March 2020

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Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

31 March 2020

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Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome

31 March 2020

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Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines

31 March 2020

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The Bloom's syndrome gene product promotes branch migration of holliday junctions

31 March 2020

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Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

31 March 2020

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BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity

31 March 2020

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RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex

31 March 2020

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Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex

31 March 2020

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RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

31 March 2020

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BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

31 March 2020

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The double-strand-break repair model for recombination

31 March 2020

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

31 March 2020

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

31 March 2020

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Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

31 March 2020

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Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast

31 March 2020

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Control of cross-over by single-strand DNA resection

31 March 2020

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The relationship between homology length and crossing over during the repair of a broken chromosome

31 March 2020

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Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae

31 March 2020

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Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

31 March 2020

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RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

31 March 2020

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

31 March 2020

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The HRDC domain of BLM is required for the dissolution of double Holliday junctions

31 March 2020

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Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing

31 March 2020

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BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

31 March 2020

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A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.

31 March 2020

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Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration

31 March 2020

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BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules

31 March 2020

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RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination

31 March 2020

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Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.

31 March 2020

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

31 March 2020

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Role for BLM in replication-fork restart and suppression of origin firing after replicative stress

31 March 2020

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Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

31 March 2020

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The Bloom's syndrome helicase can promote the regression of a model replication fork.

31 March 2020

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The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

31 March 2020

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Mus81-Eme1 are essential components of a Holliday junction resolvase

31 March 2020

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Identification of Holliday junction resolvases from humans and yeast

31 March 2020

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Replisome assembly and the direct restart of stalled replication forks

31 March 2020

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Role of the BLM helicase in replication fork management

31 March 2020

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Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

31 March 2020

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SGS1 is required for telomere elongation in the absence of telomerase

31 March 2020

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Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

31 March 2020

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

31 March 2020

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The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

31 March 2020

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Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome

31 March 2020

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S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast

31 March 2020

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Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated cells

31 March 2020

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BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

31 March 2020

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PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint

31 March 2020

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Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation

31 March 2020

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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

31 March 2020

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31 March 2020

Chromosome fragile sites

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Resolution of converging replication forks by RecQ and topoisomerase III.

31 March 2020

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The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'?

31 March 2020

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Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group

31 March 2020

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12 December 2020

Excess of rare cancers in Werner syndrome (adult progeria)

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12 December 2020

Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture

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12 December 2020

Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase

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12 December 2020

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

1 reference

12 December 2020

SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae

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12 December 2020

Identifiers

DOI

10.1038/NRC2682

1 reference

21 August 2017

1 reference

PubMed ID

19657341