(Q37584190)

21 August 2017

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title

Chapter 2. New insights into flavivirus nonstructural protein 5. (English)

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21 August 2017

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dengue virus protein NS5

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inferred from abstract

author name string

Andrew D Davidson

series ordinal

1

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21 August 2017

publication date

1 January 2009

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Advances in Virus Research

21 August 2017

published in

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21 August 2017

volume

74

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21 August 2017

page(s)

41-101

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De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase

21 August 2017

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Phosphorylation of yellow fever virus NS5 alters methyltransferase activity

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Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

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The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals

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A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

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Monoclonal antibodies identify the NS5 yellow fever virus non-structural protein in the nuclei of infected cells

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Nitric oxide radical suppresses replication of wild-type dengue 2 viruses in vitro

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The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

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Replication strategy of Kunjin virus: evidence for recycling role of replicative form RNA as template in semiconservative and asymmetric replication

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Characterization of Kunjin virus RNA-dependent RNA polymerase: reinitiation of synthesis in vitro

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Molecular and ultrastructural analysis of heavy membrane fractions associated with the replication of Kunjin virus RNA

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Comparison of centrifugation methods for molecular and morphological analysis of membranes associated with RNA replication of the flavivirus Kunjin

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7 January 2021

Methylation status of intracellular dengue type 2 40 S RNA

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7 January 2021

Identification and characterization of type 2 dengue virus replicative intermediate and replicative form RNAs

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7 January 2021

The regulation of protein function by multisite phosphorylation--a 25 year update

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7 January 2021

Nucleocytoplasmic transport enters the atomic age.

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Fine Mapping of a cis-Acting Sequence Element in Yellow Fever Virus RNA That Is Required for RNA Replication and Cyclization

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7 January 2021

Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein

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7 January 2021

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

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7 January 2021

Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

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7 January 2021

Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

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7 January 2021

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

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7 January 2021

Flavivirus methyltransferase: a novel antiviral target

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7 January 2021

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

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7 January 2021

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

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7 January 2021

Localization and functions of Japanese encephalitis virus nonstructural proteins NS3 and NS5 for viral RNA synthesis in the infected cells

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7 January 2021

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

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Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

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Structure and mechanism of mRNA cap (guanine-N7) methyltransferase

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7 January 2021

A comparison of viral RNA-dependent RNA polymerases

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7 January 2021

A 5' RNA element promotes dengue virus RNA synthesis on a circular genome

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7 January 2021

The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site.

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7 January 2021

Viral and cellular mRNA capping: past and prospects

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7 January 2021

La protein binds to NS5 and NS3 and to the 5' and 3' ends of Dengue 4 virus RNA.

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7 January 2021

Separation of functional West Nile virus replication complexes from intracellular membrane fragments

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7 January 2021

Expression and purification of enzymatically active recombinant RNA-dependent RNA polymerase (NS5) of the flavivirus Kunjin

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7 January 2021

Active site in RrmJ, a heat shock-induced methyltransferase

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7 January 2021

Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes

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7 January 2021

Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis

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7 January 2021

The vesicular stomatitis virus L protein possesses the mRNA methyltransferase activities

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7 January 2021

The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends

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7 January 2021

Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme

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7 January 2021

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

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7 January 2021

Regulation of positive-strand RNA virus replication: the emerging role of phosphorylation

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7 January 2021

A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.

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7 January 2021

Polymerase structures and function: variations on a theme?

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7 January 2021

Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation

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7 January 2021

De novo initiation of viral RNA-dependent RNA synthesis

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7 January 2021

Association between NS3 and NS5 Proteins of Dengue Virus Type 2 in the Putative RNA Replicase Is Linked to Differential Phosphorylation of NS5

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7 January 2021

cis- and trans-acting elements in flavivirus RNA replication

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7 January 2021

Essential role of cyclization sequences in flavivirus RNA replication

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7 January 2021

Biochemical characterization of a recombinant Japanese encephalitis virus RNA-dependent RNA polymerase

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7 January 2021

Functional analysis of the tick-borne encephalitis virus cyclization elements indicates major differences between mosquito-borne and tick-borne flaviviruses

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7 January 2021

The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses

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7 January 2021

Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus

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7 January 2021

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain

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7 January 2021

Classical nuclear localization signals: definition, function, and interaction with importin alpha

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7 January 2021

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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7 January 2021

Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis

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7 January 2021

A unique strategy for mRNA cap methylation used by vesicular stomatitis virus

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7 January 2021

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

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7 January 2021

Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection

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7 January 2021

Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism

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7 January 2021

Molecular biology of flaviviruses

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7 January 2021

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

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7 January 2021

Wrapping things up about virus RNA replication

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7 January 2021

Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A.

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7 January 2021

Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses

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7 January 2021

West Nile virus strain Kunjin NS5 polymerase is a phosphoprotein localized at the cytoplasmic site of viral RNA synthesis

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7 January 2021

Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5

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7 January 2021

The flavivirus polymerase as a target for drug discovery.

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7 January 2021

Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes

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7 January 2021

5'- and 3'-noncoding regions in flavivirus RNA.

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7 January 2021

SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

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7 January 2021

Preliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses

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7 January 2021

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2′-O-methyltransferase

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7 January 2021

Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation.

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7 January 2021

Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion

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7 January 2021

Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.

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7 January 2021

Gene expression in human macrophages infected with dengue virus serotype-2.

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7 January 2021

Phosphorylation of tick-borne encephalitis virus NS5 protein

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7 January 2021

Structure-function relationships among RNA-dependent RNA polymerases

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7 January 2021

De Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template Parameters

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7 January 2021

Requirements for West Nile virus (-)- and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli

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7 January 2021

Sendai virus RNA-dependent RNA polymerase L protein catalyzes cap methylation of virus-specific mRNA.

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7 January 2021

Identification of Residues Critical for the Interferon Antagonist Function of Langat Virus NS5 Reveals a Role for the RNA-Dependent RNA Polymerase Domain

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7 January 2021

High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions

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7 January 2021

Mechanisms of type-I- and type-II-interferon-mediated signalling

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7 January 2021

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements

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7 January 2021

Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.

1 reference

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7 January 2021

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

1 reference

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7 January 2021

Elevated levels of IL-8 in dengue hemorrhagic fever

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https://api.crossref.org/works/10.1016%2FS0065-3527%2809%2974002-3

7 January 2021

Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus.

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7 January 2021

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

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7 January 2021

Requirements for De Novo Initiation of RNA Synthesis by Recombinant Flaviviral RNA-Dependent RNA Polymerases

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7 January 2021

Dengue virus RNA polymerase NS5: a potential therapeutic target?

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7 January 2021

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

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7 January 2021

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

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7 January 2021

Structure of the reovirus core at 3.6 A resolution

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7 January 2021

Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution

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7 January 2021

The LAP family: a phylogenetic point of view

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7 January 2021

Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases.

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7 January 2021

Structure, mechanism, and evolution of the mRNA capping apparatus

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7 January 2021

The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitro.

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7 January 2021

Complete nucleotide sequence of the Japanese encephalitis virus genome RNA.

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7 January 2021

Bluetongue virus VP4 is an RNA-capping assembly line

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7 January 2021

Antiviral action of nitric oxide on dengue virus type 2 replication

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7 January 2021

Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity

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7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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7 January 2021

Clinical isolates of dengue virus with distinctive susceptibility to nitric oxide radical induce differential gene responses in THP-1 cells

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7 January 2021

Architecture of the flaviviral replication complex. Protease, nuclease, and detergents reveal encasement within double-layered membrane compartments

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7 January 2021

Characterization of RNA synthesis, replication mechanism, and in vitro RNA-dependent RNA polymerase activity of Japanese encephalitis virus.

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7 January 2021

Nuclear Localization of Flavivirus RNA Synthesis in Infected Cells

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7 January 2021

Initiation of viral RNA-dependent RNA polymerization

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7 January 2021

Genome cyclization as strategy for flavivirus RNA replication

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Enzymatic characterization of the full-length and C-terminally truncated hepatitis C virus RNA polymerases: function of the last 21 amino acids of the C terminus in template binding and RNA synthesis

1 reference

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The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity

1 reference

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Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses

1 reference

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Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling

1 reference

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Kunjin RNA replication and applications of Kunjin replicons

1 reference

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A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution

1 reference

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Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

1 reference

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1 reference

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1 reference

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Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.

1 reference

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A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5'- and 3'-terminal complementary sequence motifs of the viral RNA.

1 reference

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In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure

1 reference

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Identification and characterization of RNA-dependent RNA polymerase activity in recombinant Japanese encephalitis virus NS5 protein

1 reference

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Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA

1 reference

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Mutational Analysis ofEncephalitozoon cuniculimRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity

1 reference

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Structure and Function of Flavivirus NS5 Methyltransferase

1 reference

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RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNA

1 reference

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Replication and gene function in Kunjin virus

1 reference

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7 January 2021

10.1016/S0065-3527(09)74002-3

Identifiers

DOI

1 reference

21 August 2017

1 reference