(Q37592516)

21 August 2017

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title

Primary biliary cirrhosis: considerations on pathogenesis based on identification of the M2 autoantigens (English)

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primary biliary cholangitis

21 August 2017

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2

M E Gershwin

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21 August 2017

I R Mackay

1

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21 August 2017

1 January 1990

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Seminars in Immunopathology

21 August 2017

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21 August 2017

12

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21 August 2017

1

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21 August 2017

101-119

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https://scigraph.springernature.com/pub.10.1007/bf00192686

21 August 2017

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12 December 2020

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12 December 2020

The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis

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12 December 2020

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12 December 2020

Antimitochondrial antibodies of primary biliary cirrhosis recognize dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Immune complexes in primary biliary cirrhosis contain mitochondrial antigens

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12 December 2020

Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis

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12 December 2020

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12 December 2020

Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function

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12 December 2020

Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope

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12 December 2020

The association of the autoantigens of primary biliary cirrhosis with the mitochondrial H+-ATPase--a reassessment

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12 December 2020

Immunohistochemical characterization of inflammatory infiltrates in primary biliary cirrhosis

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12 December 2020

Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats

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12 December 2020

Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens

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12 December 2020

Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation

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12 December 2020

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12 December 2020

Targeting proteins into mitochondria

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12 December 2020

Evidence for the cell-surface localization of antigens cross-reacting with the "mitochondrial antibodies" of primary biliary cirrhosis

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12 December 2020

Reactivity of anti-mitochondrial autoantibodies in primary biliary cirrhosis: definition of two novel mitochondrial polypeptide autoantigens.

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12 December 2020

Are antimitochondrial antibodies in primary biliary cirrhosis induced by R(rough)-mutants of enterobacteriaceae?

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12 December 2020

Cell-mediated immunity and suppressor-T-cell defects to liver-derived antigens in families of patients with autoimmune chronic active hepatitis.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Evidence that the major primary biliary cirrhosis-specific mitochondrial autoantigen is a subunit of complex I of the respiratory chain

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12 December 2020

A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody

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12 December 2020

Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex

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12 December 2020

In situ characterization of the cell-surface antigens of the mononuclear cell infiltrate and bile duct epithelium in primary biliary cirrhosis

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12 December 2020

Two different subtypes of antimitochondrial antibodies are associated with primary biliary cirrhosis: identification and characterization by radioimmunoassay and immunoblotting

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12 December 2020

Cloning and nucleotide sequence of the gene for dihydrolipoamide acetyltransferase from Saccharomyces cerevisiae

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12 December 2020

Abnormal regulation of immunoglobulin synthesis in vitro in primary biliary cirrhosis

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12 December 2020

The E1 alpha and beta subunits of the pyruvate dehydrogenase complex are M2'd' and M2'e' autoantigens in primary biliary cirrhosis

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12 December 2020

Primary biliary cirrhosis: associations with class II major histocompatibility complex antigens

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12 December 2020

Familial Abnormalities of Suppressor-Cell Function in Systemic Lupus Erythematosus

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12 December 2020

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12 December 2020

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12 December 2020

Pathogenic mechanisms in primary biliary cirrhosis

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12 December 2020

Immunohistochemical characterization of inflammatory infiltrates at the site of bile duct injury in primary biliary cirrhosis

1 reference

12 December 2020

The pyruvate dehydrogenase complex of Escherichia coli K12. Nucleotide sequence encoding the dihydrolipoamide acetyltransferase component.

1 reference

12 December 2020

Identity of the M2 autoantigens in primary biliary cirrhosis

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12 December 2020

Nucleotide sequence of a cDNA encoding the lipoate acetyl transferase (E2) of human heart pyruvate dehydrogenase complex differs from that of human placenta.

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12 December 2020

T- and B-cell recognition of hepatitis B viral antigens

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12 December 2020

Mitochondrial antibodies in primary biliary cirrhosis: species and nonspecies specific determinants of M2 antigen

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12 December 2020

Auto-epitopes and autoimmune diseases.

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12 December 2020

Autoantibodies are anti-idiotype antibodies to antiviral antibodies

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12 December 2020

Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritis

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12 December 2020

Clonal analysis of human T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis

1 reference

12 December 2020

Clinical and prognostic relevance of different mitochondrial antibody profiles in primary biliary cirrhosis (PBC).

1 reference

12 December 2020

The role of the human anti-DNA idiotype 16/6 in autoimmunity

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12 December 2020

Heterogeneity of antimitochondrial antibodies

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12 December 2020

Impaired delayed hypersensitivity in primary biliary cirrhosis.

1 reference

12 December 2020

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme

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12 December 2020

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12 December 2020

Deficiency of the autologous mixed lymphocyte reaction in patients with primary biliary cirrhosis

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12 December 2020

Primary biliary cirrhosis in elderly females

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12 December 2020

Antimitochondrial antibodies in primary biliary cirrhosis

1 reference

12 December 2020

Aberrant expression of HLA-DR antigens on bileduct epithelium in primary biliary cirrhosis: relevance to pathogenesis

1 reference

12 December 2020

Tolerance to an autoantigen-thyroglobulin. Antigen-binding lymphocytes in thymus and blood in health and autoimmune disease

1 reference

12 December 2020

Primary billiary cirrhosis in the elderly.

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12 December 2020

Immune suppression genes.

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12 December 2020

Circulating immune complexes and complement activation in primary biliary cirrhosis

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12 December 2020

Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity

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12 December 2020

Studies on the autologous MLR in primary biliary cirrhosis: evidence that the autologous MLR is a negative feedblock response stimulated by activated B cells

1 reference

12 December 2020

Primary biliary cirrhosis

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12 December 2020

Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis

1 reference

12 December 2020

Lymphocyte Subsets in Primary Biliary Cirrhosis

1 reference

12 December 2020

Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein

1 reference

12 December 2020

Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases

1 reference

12 December 2020

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis

1 reference

12 December 2020

Heterogeneity of antimitochondrial antibodies with the M2-M4 pattern by immunofluorescence as assessed by Western immunoblotting and enzyme linked immunosorbent assay

1 reference

12 December 2020

Evidence against an immune complex pathogenesis of primary biliary cirrhosis

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12 December 2020

T-lymphocyte subsets in liver tissues of patients with primary biliary cirrhosis (PBC), patients with primary sclerosing cholangitis (PSC), and normal controls

1 reference

12 December 2020

The predominance of IgG3 and IgM isotype antimitochondrial autoantibodies against recombinant fused mitochondrial polypeptide in patients with primary biliary cirrhosis.

1 reference

12 December 2020

Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis

1 reference

12 December 2020

Immunology: The ins and outs of antigen processing and presentations

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12 December 2020

Identifiers

DOI

10.1007/BF00192686

1 reference

21 August 2017

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PubMed ID

1973308